Study of extra-articular manifestations and disease severity in patients with rheumatoid arthritis

Kalappan, Mahendrakumar; Abubacker, Naufal Rizwan Taraganar; Shetty, Meenakshi; Rajendran, Kannan; Rathinam, Warun Kumar Muthupillai; Karuthodiyil, Rajendran

doi:10.18203/2349-3933.ijam20160188

Cited by 2 publications

(5 citation statements)

References 2 publications

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“…There was no association between extra-articular manifestation and disease activity in RA patients, suggesting that although extra-articular manifestation was reported upon diagnosis, the patient did not necessarily demonstrate active disease. This observation was different from another study [9] that suggested a significant association between extra-articular manifestation and disease severity. This might be due to differences in extra-articular manifestations in the authors’ study which included pulmonary manifestation namely interstitial lung disease, pleural effusion, and obstructive airway disease, and neurological manifestation.…”

Section: Discussioncontrasting

confidence: 99%

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Anti-cyclic citrullinated peptide antibody is highly associated with rheumatoid factor and radiological defects in rheumatoid arthritis patients

Sulaiman¹,

Wong²,

Ahmad

et al. 2019

Medicine

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Rheumatoid arthritis (RA) is a chronic debilitating inflammatory disease affecting mainly the joint, surrounding tissue and other extra-articular structures in the body. RA can lead to destruction of bone and cartilage which may cause severe disability and it is characterized by the presence of serum rheumatoid factor (RF). The anti-cyclic citrullinate peptide (anti-CCP) antibody is another serum biomarker used in RA diagnosis with higher sensitivity and specificity. In this cross-sectional study with retrospective record review, 159 established RA patients from Hospital Universiti Sains Malaysia (HUSM) were recruited. Enzyme-linked immunosorbent assays (ELISAs) for serum RF and anti-CCP were performed. Our goal was to evaluate the significance of anti-CCP antibody in predicting the disease activity and progression in terms of radiological and extra-articular manifestations upon diagnosis. Of the 159 RA patients included in this study, mean age was 48.3 years old and majority (n = 134; 84.3%) were female. A total of 83 (52.2%) and 99 (62.3%) patients had anti-CCP antibody and RF, respectively. Mean Disease Activity Score-28 for Rheumatoid Arthritis with erythrocyte sedimentation rate (ESR) (DAS28-ESR) score for all patients was 4.74 (medium and high disease activity). Fifty-eight (36.5%) patients had radiological defects and 49 (30.8%) patients had extra-articular involvement manifested by rheumatoid nodule, pulmonary involvement, and anemia. In terms of anti-CCP antibody association with clinical and laboratory parameters, a significant co-occurrence of RF and anti-CCP antibody ( P = .002) was observed. Anti-CCP antibody was significantly associated with radiological defects in which majority of patients with such defects (n = 40/58; 68.9%) were positive for anti-CCP antibody ( P = .001). However, there was no significant difference between mean and classes of disease activity score and extra-articular manifestations between different anti-CCP antibody groups. In addition, extra-articular manifestations were not associated with high disease activity upon RA diagnosis There was a significant association between anti-CCP antibody positivity and positive RF. Radiological defects were the sole clinical parameter significantly associated with anti-CCP antibody positivity, indicating that patients positive for anti-CCP antibody should be routinely monitored for radiological defects and their onset.

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Section: Discussioncontrasting

confidence: 99%

“…The development of radiological involvement with extra-articular manifestation in high disease activity patients was consistent with previous studies. [7–9]…”

Section: Discussionmentioning

confidence: 99%

Anti-cyclic citrullinated peptide antibody is highly associated with rheumatoid factor and radiological defects in rheumatoid arthritis patients

Sulaiman¹,

Wong²,

Ahmad

et al. 2019

Medicine

View full text Add to dashboard Cite

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“…It is typically characterized by symmetrical, destructive, and deforming polyarthritis of small and large joints with various extraarticular manifestations. [1][2][3] RA is an autoimmune disorder with a female preponderance and a worldwide prevalence of 1-2%. 4 The extra-articular manifestations of RA could be respiratory, cardiac, neurological, renal, ocular, or hematological.…”

Section: Introductionmentioning

confidence: 99%

“…Pulmonary involvement is the most common among these manifestations. 1 The pulmonary manifestations of RA could be due to the disease or the drugs used in its treatment. It is unclear if radiological features in the lung precede symptoms and if early institution of diseasemodifying anti-rheumatic drugs (DMARDS) can delay the occurrence of pulmonary manifestations in RA.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and radiological correlation of pulmonary manifestations in rheumatoid arthritis

Srilakshmi M Prabhu,

Ram Shenoy Basti

2024

Asian J Med Sci

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Background: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis with various extra-articular manifestations, pulmonary being the most involved. Aims and Objectives: This study aims to identify the radiological patterns in the lungs among patients with RA. Materials and Methods: A total of 39 patients with RA were chosen randomly. They were examined and imaged by chest X-ray and high-resolution computed tomography (HRCT) thorax, and findings were analyzed. Results: The mean age of patients was 53.9 and had a female preponderance of 74.4%. Among the 39 patients studied, 30 had no respiratory symptoms. The most common HRCT thorax findings were bronchiectasis and ground-glass opacities. Conclusion: Radiological pulmonary manifestations of RA identified in HRCT imaging are wide and occur in the majority of clinically asymptomatic patients.

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Study of extra-articular manifestations and disease severity in patients with rheumatoid arthritis

Cited by 2 publications

References 2 publications

Anti-cyclic citrullinated peptide antibody is highly associated with rheumatoid factor and radiological defects in rheumatoid arthritis patients

Anti-cyclic citrullinated peptide antibody is highly associated with rheumatoid factor and radiological defects in rheumatoid arthritis patients

Clinical and radiological correlation of pulmonary manifestations in rheumatoid arthritis

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