Study of fatigue resistance of chemical and radiation crosslinked medical grade ultrahigh molecular weight polyethylene

Baker, David; Hastings, Robert S.; Pruitt, Lisa A.

doi:10.1002/(sici)1097-4636(19990915)46:4<573::aid-jbm16>3.0.co;2-a

Cited by 139 publications

(52 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The higher crack driving force required for crack initiation in the 25 and 50 kGy cross-linked UHM-WPE's is consistent with the findings from the fatigue studies of Baker et al [1,2] and O'Connor et al [20]. In the former study, notched specimens of cross-linked and uncross-linked UHMWPE were fatigue tested, thus examining resistance to crack propagation with a conclusion that fracture toughness reduced with cross-linking.…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

J‐integral fracture toughness and tearing modulus measurement of radiation cross‐linked UHMWPE

Gomoll¹,

Wanich²,

Bellare³

2002

Journal Orthopaedic Research

View full text Add to dashboard Cite

Radiation and chemical cross-linking of medical grade ultrahigh molecular weight polyethylene (UHMWPE) has recently been utilized in an effort to improve wear performance of total joint replacement components. However, reductions in mechanical properties with cross-linking are cause for concern regarding the use of cross-linked UHMWPE for high-stress applications such as in total knee replacement prostheses. In this study, the fracture behavior of radiation cross-linked UHMWPE was compared to that of uncross-linked UHMWPE. The Rice and Sorensen model that utilizes mechanical parameters obtained from uniaxial tensile and compact tension tests was used to calculate the steady state J-integral fracture toughness, J,,, for radiation cross-linked UHMWPE. J,, decreased monotonically with increase in radiation dose. UHMWPE exhibited tough, ductile tearing behavior with stable crack growth when it was cross-linked using a gamma radiation dose of 0-50 kGy. However. in cross-linked UHMWPE irradiated to a dose of 100 and 300 kCy, unstable fracture occurred spontaneously upon attaining the initial crack driving force, J,,. This indicates that a high degree of cross-linking is less desirable for high-stress applications in orthopaedic implants. However, a substantial increase in JI,, even at a low degree of cross-linking, suggests that a low degree of cross-linking may be beneficial for resistance to delamination and catastrophic failure, both of which require an initiation step for the fracture to propagate in the material. This mechanical test should, however, be considered along with fatigue tests and joint simulator testing before determination of an appropriate amount of cross-linking for total joint replacement prostheses that experience high stresses.

show abstract

Section: Discussionsupporting

confidence: 84%

“…mechanical properties such as fracture toughness, modulus of elasticity, ultimate tensile strength, yield strength, hardness, and resistance to fatigue crack propagation [ 1, 2,12,18]; these limitations are cause for concern regarding the use of cross-linked UHMWPE for high-stress applications such as in total knee replacement prostheses.…”

mentioning

confidence: 99%

J‐integral fracture toughness and tearing modulus measurement of radiation cross‐linked UHMWPE

Gomoll¹,

Wanich²,

Bellare³

2002

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…The fatigue strength increases with crystallinity and decreases with crosslinking [5,34,45,79,81]. While conventional UHMWPE has high crystallinity and fatigue strength in its unaged form, its fatigue resistance is severely deteriorated due to oxidation [58,66].…”

Section: Discussionmentioning

confidence: 99%

Vitamin E-stabilized UHMWPE for Total Joint Implants: A Review

Bracco

Oral

2011

Clinical Orthopaedics &Amp; Related Research

256

162

View full text Add to dashboard Cite

Background Osteolysis due to wear of UHMWPE limits the longevity of joint arthroplasty. Oxidative degradation of UHMWPE gamma-sterilized in air increases its wear while decreasing mechanical strength. Vitamin E stabilization of UHMWPE was proposed to improve oxidation resistance while maintaining wear resistance and fatigue strength. Questions/purposes We reviewed the preclinical research on the development and testing of vitamin E-stabilized UHMWPE with the following questions in mind: (1) What is the rationale behind protecting irradiated UHMWPE against oxidation by vitamin E? (2) What are the effects of vitamin E on the microstructure, tribologic, and mechanical properties of irradiated UHMWPE? (3) Is vitamin E expected to affect the periprosthetic tissue negatively? Methods We performed searches in PubMed, Scopus, and Science Citation Index to review the development of vitamin E-stabilized UHMWPEs and their feasibility as clinical implants.Results The rationale for using vitamin E in UHMWPE was twofold: improving oxidation resistance of irradiated UHMWPEs and fatigue strength of irradiated UHMWPEs with an alternative to postirradiation melting. Vitamin E-stabilized UHMWPE showed oxidation resistance superior to that of irradiated UHMWPEs with detectable residual free radicals. It showed equivalent wear and improved mechanical strength compared to irradiated and melted UHMWPE. The biocompatibility was confirmed by simulating elution, if any, of the antioxidant from implants.Conclusions Vitamin E-stabilized UHMWPE offers a joint arthroplasty technology with good mechanical, wear, and oxidation properties. Clinical Relevance Vitamin E-stabilized, irradiated UHMWPEs were recently introduced clinically. The rationale behind using vitamin E and in vitro tests comparing its performance to older materials are of great interest for improving longevity of joint arthroplasties.

show abstract

“…Research in other laboratories [43][44][45][46][47] has documented the improvements in wear properties and the changes in physical properties of polymers that have been cross linked as a part of the material processing or sterilization process. In addition, research on the same equipment used for the current study with the same protocols 48 -50 has shown that the cross-linked polyethylenes may exhibit wear properties that yield gravimetric weight losses very similar to those for the metal-on-metal samples.…”

Section: Discussionmentioning

confidence: 99%

Wear evaluation of cobalt–chromium alloy for use in a metal‐on‐metal hip prosthesis

John

Zardiackas

Poggie³

2003

J Biomed Mater Res

View full text Add to dashboard Cite

Wear of the polyethylene in total joint prostheses has been a source of morbidity and early device failure, which has been extensively reported in the last 20 years. Although research continues to attempt to reduce the wear of polyethylene joint-bearing surfaces by modifications in polymer processing, there is a renewed interest in the use of metal-on-metal bearing couples for hip prostheses. Wear testing of total hip replacement systems involving the couple of metal or ceramic heads on polymeric acetabular components has been performed and reported, but, until recently, there has been little data published for pin-on-disk or hip-simulator wear studies involving the combination of a metallic femoral head component with an acetabular cup composed of the same or a dissimilar metal. This study investigated the in vitro wear resistance of two cobalt/chromium/molybdenum alloys, which differed primarily in the carbon content, as potential alloys for use in a metal-on-metal hip-bearing couple. The results of pin-on-disk testing showed that the alloy with the higher (0.25%) carbon content was more wear resistant, and this alloy was therefore chosen for testing in a hip-simulator system, which modeled the loads and motions that might be exerted clinically. Comparison of the results of metal-on-polyethylene samples to metal-on-metal samples showed that the volumetric wear of the metal-on-polyethylene bearing couple after 5,000,000 cycles was 110 -180 times that for the metal-bearing couple. Polyethylene and metal particles retrieved from either the lubricant for pin-on-disk testing or hip simulator testing were characterized and compared with particles retrieved from periprosthetic tissues by other researchers, and found to be similar. Based upon the results of this study, metal-on-metal hip prostheses manufactured from the high carbon cobalt/chromium alloy that was investigated hold sufficient promise to justify human clinical trials.

show abstract

Study of fatigue resistance of chemical and radiation crosslinked medical grade ultrahigh molecular weight polyethylene

Cited by 139 publications

References 16 publications

J‐integral fracture toughness and tearing modulus measurement of radiation cross‐linked UHMWPE

J‐integral fracture toughness and tearing modulus measurement of radiation cross‐linked UHMWPE

Vitamin E-stabilized UHMWPE for Total Joint Implants: A Review

Wear evaluation of cobalt–chromium alloy for use in a metal‐on‐metal hip prosthesis

Contact Info

Product

Resources

About