Study of flow effects on temperature‐controlled radiofrequency ablation using phantom experiments and forward simulations

Nolte, Teresa; Vaidya, Nikhil; Baragona, Marco; Elevelt, Aaldert; Lavezzo, Valentina; Maessen, Ralph; Schulz, Volkmar; Veroy, Karen

doi:10.1002/mp.15138

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A common approach is to perform initial tests and optimization in a laboratory setting on inanimate objects called phantoms 12 . These phantoms can vary from being relatively simple 13 covering basic anatomy to fairly complex allowing for tuning the material characteristics 14 and mimicking more realistic anatomical geometries 14 as well as incorporating physiologic parameters such as blood flow 15,16 . Several thyroid phantoms, intended for training and research into biopsies and thermal ablations, are described in the literature.…”

Section: Introductionmentioning

confidence: 99%

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Boers,

Brink,

Bianchi

et al. 2023

Medical Physics

View full text Add to dashboard Cite

BackgroundNeedle‐based procedures, such as fine needle aspiration and thermal ablation, are often applied for thyroid nodule diagnosis and therapeutic purposes, respectively. With blood vessels and nerves nearby, these procedures can pose risks in damaging surrounding critical structures.PurposeThe development and validation of innovative strategies to manage these risks require a test object with well‐characterized physical properties. For this work, we focus on the application of ultrasound‐guided thermal radiofrequency ablation.MethodsWe have developed a single‐use anthropomorphic phantom mimicking the thyroid and surrounding anatomical and physiological structures that are relevant to ultrasound‐guided thermal ablation. The phantom was composed of a mixture of polyacrylamide, water, and egg white extract and was cast using molds in multiple steps. The thermal, acoustical, and electrical characteristics were experimentally validated. The ablation zones were analyzed via non‐destructive T2‐weighted magnetic resonance imaging scans utilizing the relaxometry changes of coagulated egg albumen, and the temperature distribution was monitored using an array of fiber Bragg grating sensors.ResultsThe physical properties of the phantom were verified both on ultrasound as well as in terms of the phantom response to thermal ablation. The final temperature achieved (92°C), the median percentage of the nodule ablated (82.1%), the median volume ablated outside the nodule (0.8 mL), and the median number of critical structures affected (0) were quantified.ConclusionAn anthropomorphic phantom that can provide a realistic model for development and training in ultrasound‐guided needle‐based thermal interventions for thyroid nodules has been presented.

show abstract

Section: Introductionmentioning

confidence: 99%

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Boers,

Brink,

Bianchi

et al. 2023

Medical Physics

View full text Add to dashboard Cite

show abstract

Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

Negussie,

Morhard,

Rivera

et al. 2024

Functional Composite Mater

View full text Add to dashboard Cite

Heat-based local ablation techniques are effective treatments for specific oligometastatic and localized cancers and are being studied for their potential to induce immunogenic cell death and augment systemic immune responses to immunotherapies. The diverse technologies associated with thermal therapy have an unmet need for method development to enable device-specific experimentation, optimization, calibration and refinement of the parameter space to optimize therapeutic intent while minimizing side effects or risk to the patient. Quality assurance, training, or comparing thermal dose among different modalities or techniques using animal models is time and resource intensive. Therefore, the application and use of tissue mimicking thermosensitive, thermochromic liquid crystal and thermochromic paint phantom models may reduce costs and hurdles associated with animal use. Further, their homogenous composition may enable more precise assessment of ablative techniques. This review utilized SciFinder, Web of Science, PubMed and EMBASE to systematically evaluate the literature describing the background and applications of thermochromic liquid crystal, thermochromic paint and tissue-mimicking thermochromic phantoms used to characterize the thermal effects of ablation devices with a focus on facilitating their use across the medical device development life cycle. Graphical Abstract

show abstract

Study of flow effects on temperature‐controlled radiofrequency ablation using phantom experiments and forward simulations

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 2 publications

References 47 publications

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

Contact Info

Product

Resources

About