STUDY OF GENETIC POLYMORPHISM OF DNA METHYLTRANSFERASE DNMT3B IN THE PATIENTS WITH NONSMALL CELL LUNG CANCER

Abstract

The effect of polymorphic variants of the DNMT3B gene on the risk of non-small cell lung cancer (NSCLC) development and its clinical characteristics was assessed. To identify rs1569686 (–579G > T) and rs2424913 (–149C > T) polymorphisms in the promoter region of the DNMT3B gene, a PCR-RFLP method was used. The risk significance of –579GT + TT (OR = 1.73; 95% CI: 1.11–2.71) and –149 CT + TT (OR = 1.59; 95% CI: 1.00–2.50) in
 the development of a more common tumor process in the case of non-small cell lung cancer was shown. Individuals over 60 years with the –579TT DNMT3B genotype are subjects to an increased risk of non-small cell lung cancer development (OR = 2.49; 95% CI: 1.15–5.40) and squamous cell lung cancer (OR = 4.39; 95% CI: 1.36–14.13). It was found that among smoking patients compared with non-smoking patients, there are significantly more carriers of –149TT (OR = 2.39; 95% CI: 1.16–6.93) and –579TT (OR = 3.05; 95 % CI: 1.36–6.85) genotypes. The same dependence sustained in the case of smoking patients with squamous cell lung cancer.