Study of Global Longitudinal Strain And N-Terminal Pro Brain Natriuretic Peptide as Predictors of Outcome in Acute St-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Interventions

Abstract

Objective: Acute ST-segment elevation myocardial infarction (STEMI) patients should be risk-stratified in order to enhance the outcome. Our study was designed to assess the prognostic value of N-terminal pro brain natriuretic peptide (NT-proBNP) and global longitudinal strain (GLS) of the left ventricle in patients presenting with acute STEMI and treated by primary percutaneous coronary interventions (PPCI). Methods: the study included 100 STEMI patients treated by PPCI, their age was 55.69 ±8.70 years, all patients were subjected to analysis of NT-proBNP plasma level, and calculation of the GLS, and follow up was done for 6 months for major adverse cardiac events (MACE) occurrence. Results: patients were divided into two groups according to MACE, group I (20 patients who had MACE), group II (80patients without MACE), the NT-proBNP was significantly higher and the GLS was significantly lower in group I, and by multivariate regression analysis GLS was shown to be the most significant predictor of MACE (p value=0.003). Conclusions: Our study concluded that both GLS and NT-proBNP are significantly related to MACE, with GLS being the single most significant predictor for MACE in patients with acute STEMI treated by PPCI.