Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus

Abstract

Introduction: Diabetes Mellitus is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Objective: To compare the biochemical parameters which included glycated hemoglobin, serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of people with diabetes mellitus and matched nondiabetic controls. Methods: The cross-sectional hospital-based study was conducted among 60 diabetics and 30 nondiabetic patients. Fasting blood samples of 5 ml were collected from both the study sample and control sample. Biochemical parameters like glycated hemoglobin, serum total cholesterol, serum triglyceride, serum high-density lipoprotein cholesterol, and serum low-density lipoprotein cholesterol were analyzed with the help of a semi-automated analyzer, Erba Chem5, and Colorimeter-Systronic. Means of glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were estimatedamong the cases and controls. The student`s t-test was used to compare the mean values. Results: A statistically significant difference was observed in mean glycated hemoglobin, total cholesterol, triglyceride, high density lipoprotein and low-density lipoprotein among the cases and controls (p-value<0.05). Conclusions: This study concluded that there was a significant difference in mean glycated hemoglobin, total cholesterol, triglyceride, high-density cholesterol, and low-density cholesterol among the cases and controls. It is suggestive that lipid profile must be considered among diabetic patients which could be beneficial to prevent the risk of cardiovascular complications.

Correlation of Glycated Hemoglobin with Serum Triglyceride to High Density Lipoprotein Ratio in Type 2 Diabetes Mellitus Patients

“…In agreement with the study by Young KA et al who have shown the association of TG/ HDL ratio withβ cell functionand insulin sensitivity. 16 The current study revealed the increment of TG, TC, LDL, and decrement of serum HDL when compared with the healthy subjects, these findings are consistent with a study conducted at Khammam, Andra Pradesh, India by Yadav T et al 17 However, they didn't report the correlation of the TG/HDL ratio with glycated hemoglobin in their study population.…”

Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile

“…These findings are in accordance with a study which also revealed reduced ABCA1 expression in type 2 diabetic study participants 22 . HbA1c has been found to be a good diagnostic tool in cases of prediabetes and diabetes in the country, as well as a good predictor of lipid profile [23][24][25] . A positive association of HbA1c has been reported with macro and microvascular complications of diabetes mellitus type 2 26 .…”