Study of gray matter atrophy pattern with subcortical ischemic vascular disease-vascular cognitive impairment no dementia based on structural magnetic resonance imaging

Tan, Lin; Xing, Jian; Wang, Zhenqi; Du, Xuehui; Luo, Ruidi; Wang, Jianhang; Zhao, Jing; Zhao, Weina; Yin, Changhao

doi:10.3389/fnagi.2023.1051177

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Such alterations may play a crucial role in the development and manifestation of subcortical VCI. The findings of this study provide valuable evidence that helps in explaining the underlying mechanisms of subcortical VCI ( 16 ). It highlights the importance of identifying and understanding the structural changes occurring in the brain, which can contribute to better diagnosis, management, and treatment strategies for patients with subcortical VCI.…”

Section: Introductionmentioning

confidence: 83%

“…In their study, Tan and colleagues aimed to investigate the structural imaging changes occurring in patients with SIVD-VCIND and SIVD-VaD, which are subtypes of SIVD ( 16 ). They found that gray matter atrophy was observed in multiple brain regions in both groups.…”

Section: Introductionmentioning

confidence: 99%

“…They found that gray matter atrophy was observed in multiple brain regions in both groups. Specifically, in the SIVD-VCIND group, it was detected in the bilateral orbitofrontal gyrus, right middle temporal gyrus, superior temporal gyrus, and anterior cuneiform lobe ( 16 ). This suggests that the patients with SIVD-VCIND showed degeneration in these areas of the brain.…”

Section: Introductionmentioning

confidence: 99%

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A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment

Wei,

Yue,

et al. 2023

Front. Neurol.

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Vascular cognitive impairment (VCI) is the initial stage of vascular dementia (VaD). Early diagnosis and treatment of VCI are crucial to prevent the progression of VaD. In order to gain a better understanding of VCI, this study aimed to investigate the use of advanced imaging techniques such as structural magnetic resonance imaging (sMRI) and resting-state functional magnetic resonance imaging (rs-fMRI). These techniques allow researchers to observe the structural and functional changes in the brain that are associated with VCI. Functional magnetic resonance imaging (fMRI) and sMRI techniques have been widely used in studies focusing on gray matter, brain networks, and functional abnormalities during rest. By searching and summarizing recent literature, this study has provided valuable evidence on the use of advanced imaging techniques in understanding and treating VCI. The findings from this study can aid in the development of early intervention strategies for patients with VCI, potentially slowing down or even halting the progression of VCI to full-blown VaD.

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Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment

Wei,

Yue,

et al. 2023

Front. Neurol.

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“…The temporal lobe plays a crucial role in the normal memory function and the processing of auditory information ( Tan et al, 2023 ). Our study observed significant associations between the atrophy of left middle temporal gyrus and the decreased auditory memory scores in SIVD-CI group.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease

Huang,

Cheng,

Liu

et al. 2024

Front. Neurosci.

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IntroductionPrior MRI studies have shown that patients with subcortical ischemic vascular disease (SIVD) exhibited white matter damage, gray matter atrophy and memory impairment, but the specific characteristics and interrelationships of these abnormal changes have not been fully elucidated.Materials and methodsWe collected the MRI data and memory scores from 29 SIVD patients with cognitive impairment (SIVD-CI), 29 SIVD patients with cognitive unimpaired (SIVD-CU) and 32 normal controls (NC). Subsequently, the thicknesses and volumes of the gray matter regions that are closely related to memory function were automatically assessed using FreeSurfer software. Then, the volume, fractional anisotropy (FA), mean diffusivity (MD), amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values of white matter hyperintensity (WMH) region and normal-appearing white matter (NAWM) were obtained using SPM, DPARSF, and FSL software. Finally, the analysis of covariance, spearman correlation and mediation analysis were used to analyze data.ResultsCompared with NC group, patients in SIVD-CI and SIVD-CU groups showed significantly abnormal volume, FA, MD, ALFF, and ReHo values of WMH region and NAWM, as well as significantly decreased volume and thickness values of gray matter regions, mainly including thalamus, middle temporal gyrus and hippocampal subfields such as cornu ammonis (CA) 1. These abnormal changes were significantly correlated with decreased visual, auditory and working memory scores. Compared with the SIVD-CU group, the significant reductions of the left CA2/3, right amygdala, right parasubiculum and NAWM volumes and the significant increases of the MD values in the WMH region and NAWM were found in the SIVD-CI group. And the increased MD values were significantly related to working memory scores. Moreover, the decreased CA1 and thalamus volumes mediated the correlations between the abnormal microstructure indicators in WMH region and the decreased memory scores in the SIVD-CI group.ConclusionPatients with SIVD had structural and functional damages in both WMH and NAWM, along with specific gray matter atrophy, which were closely related to memory impairment, especially CA1 atrophy and thalamic atrophy. More importantly, the volumes of some temporomesial regions and the MD values of WMH regions and NAWM may be potentially helpful neuroimaging indicators for distinguishing between SIVD-CI and SIVD-CU patients.

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“…의 수행력이 DAT와 유사하고 (Freitas et al, 2018;Villardita, 1993), vMCI의 경우 MCI-nov보다 수행력이 저하되는 것으로 나타나거나 (Nordlund et al, 2007) 수행력에 유의미한 차이가 없다는 연구도 함께 보고되었다 (Nyström et al, 2015). Reiter, 2000;Kaul et al, 2022;Lee et al, 2017;Lukatela et al, 1998;Park et al, 2006;Paul et al, 2001a;Tan et al, 2023;Traykov et al, 2005;Villardita, 1993;Vuorinen et al, 2000) DAT와 비교하여 수행력이 높다는 결과가 많았다 (Braaten et al, 2006;Freitas et al, 2018;Golden et al, 2005;Knopman et al, 2011;Lukatela et al, 1998;Morris et al, 2016;Oh et al, 2010;Vuorinen et al, 2000). 이와 반대로 DAT보다 대면이름대기 수행력이 저하된다는 보고 (Er et al, 2017;Jang & Kim, 2012;Lee et al, 2017)와 유의미한 차 이가 나타나지 않았다는 보고도 일부에서 확인되었다 (Baillon et al, 2003;Bentham et al, 1997;Lafosse et al, 1997;Laine et al, 1997;Park et al, 2006;Villardita, 1993).…”

Section: 토큰 검사의 수행력을 환자군 간 비교하여 살펴보았을 때 Vadunclassified

A Literature Review of Language Characteristics in Patients with Vascular Dementia

Kwon,

Lee,

Yoon

2024

Audiol Speech Res

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Vascular dementia may present with language disorders due to damage to frontal subcortical circuits. This study aimed to review recent studies of language abilities in patients with vascular dementia. Sixty-nine studies were classified according to language modalities (spontaneous speech, auditory comprehension, repetition and naming). First, spontaneous speech was impaired in the ability to describe pictures, objects and in the ability to convey information in discourse. Second, the auditory comprehension was impaired in word comprehension, sentence comprehension, paragraph comprehension, and speech act comprehension tasks. Third, repetition was preserved in word-level tasks but impaired at the sentence level. Fourth, the naming performance was impaired in a generative naming task (phonemic fluency) rather than in a confrontational naming task. Therefore, when summarizing the results between patient groups, in spontaneous speech, to convey information through highly informative utterances was relatively good in vascular dementia (VaD), but the number of utterances was lower than dementia of Alzheimer’s type (DAT). In auditory comprehension, VaD’s performance was good in the task of word comprehension and speech act comprehension tasks. It is organized as in repetition, VaD’s performance was relatively good in the sentence-level task, and in naming, VaD’s performance was reported to be better than DAT in the oppositional naming and generative naming semantic category tasks. In the generative naming phoneme category, opposite result was reported. Further studies on the language abilities of patients with vascular dementia needs to consider factors such as subtype and language modality. Future studies should be evenly distributed across all language domains.

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Study of gray matter atrophy pattern with subcortical ischemic vascular disease-vascular cognitive impairment no dementia based on structural magnetic resonance imaging

Cited by 8 publications

References 26 publications

A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment

A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment

Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease

A Literature Review of Language Characteristics in Patients with Vascular Dementia

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