Study of Hepatitis B Virus Infection and Its Genotypes in Tribal People

Abstract

Objective: This study was undertaken to screen the epidemiology of hepatitis B virus (HBV) in ethnically distinct, tribal dominated and of lower socioeconomic status area.Methods: Briefly, 3 ml blood was collected from 50 random liver disease cases with jaundice, receiving care at Central Hospital, N.F. Railway, Guwahati, and Guwahati Medical College, with informed consent. The patients detected with hepatitis A virus (HAV)-immunoglobulin M positive status were included and were stratified as acute viral hepatitis and fulminant hepatitis failure based on the clinical profile. HAV genotyping was studied by polymerase chain reaction-direct sequencing-phylogenetic analysis approach. Statistical analysis was performed using SPSS 13.0 software. Result:A total of 50 cases were HBV infected. HBV infection was predominant in the young and adult age group. HBV-RNA was detected in 19 cases. Conclusion:This study shows that HBV genotype D is most commonly found hepatitis in all tribes of Assam and poor sanitation and alcohol consumption are a common reason for its widespread.

Virtual Screening of Indonesian Herbal Database for Cp Allosteric Modulator of Hepatitis B Virus

“…Hepatitis B is an inflammation of the liver caused by the hepatitis B virus (HBV). HBV is transmitted hematogenously and sexually, causing a complicated viral-host interaction which results in either an acute symptomatic disease or an asymptomatic disease [1]. Hepatitis B is the most serious type of viral hepatitis and one of the major problems of global public health [2].…”