Study of HLA Class I gene in Indian schizophrenic patients of Siliguri, West Bengal

Singh, Bisu; Bera, Nirmal Kumar; De, Santanu; Nayak, Chittaranjan; Chaudhuri, Tapas Kumar

doi:10.1016/j.psychres.2011.03.010

Cited by 10 publications

(8 citation statements)

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“…Curiously though, the extended MHC region was reported to be associated with schizophrenia in Chinese Han population, and a number of schizophrenia-related genes including MICB [20], HLA-A and HLA-B [21] are classic MHC molecules that play central roles in the development of host defense and immunity. Since multiple genes-especially in the same pathway or having similar functions-may interact in a nonlinear mode to influence susceptibility [9], better understanding of gene-gene interactions may be a more sensitive method of characterizing the effects of candidate genes on schizophrenia [4].…”

Section: Discussionmentioning

confidence: 99%

An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

Wang

Lu²,

et al. 2015

Neuroscience Letters

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Section: Discussionmentioning

confidence: 99%

An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

Wang

Lu²,

et al. 2015

Neuroscience Letters

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“…MICB, HLA-A, and HLA-B are classic MHC molecules that play central roles in the development of host defense and immunity [38], [39]. Tumor necrosis factor α (TNFα), located in the classic class III subregion, encodes a cytokine involved in systemic inflammation and acute-phase reactions [40], [41].…”

Section: Discussionmentioning

confidence: 99%

Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population

Zhang

Yan

et al. 2013

PLoS ONE

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Chromosome 6p21-p22.1, spanning the extended major histocompatibility complex (MHC) region, is a highly polymorphic, gene-dense region. It has been identified as a susceptibility locus of schizophrenia in Europeans, Japanese, and Chinese. In our previous two-stage genome-wide association study (GWAS), polymorphisms of zinc finger with KRAB and SCAN domains 4 (ZKSCAN4), nuclear factor-κB-activating protein-like (NKAPL), and piggyBac transposable element derived 1 (PGBD1), localized to chromosome 6p21-p22.1, were strongly associated with schizophrenia. To further investigate the association between polymorphisms at this locus and schizophrenia in the Chinese Han population, we selected eight other single-nucleotide polymorphisms (SNPs) distributed in or near these genes for a case-control association study in an independent sample of 902 cases and 1,091 healthy controls in an attempt to replicate the GWAS results. Four of these eight SNPs (rs12214383, rs1150724, rs3800324, and rs1997660) displayed a nominal difference in allele frequencies between the case and control groups. The association between two of these SNPs and schizophrenia were significant even after Bonferroni correction (rs12000: allele A>G, P = 2.50E-04, odds ratio [OR] = 1.27, 95% confidence interval [CI] = 1.12–1.45; rs1150722: allele C>T, P = 4.28E-05, OR = 0.55, 95% CI = 0.41–0.73). Haplotype ATTGACGC, comprising these eight SNPs (rs2235359, rs2185955, rs12214383, rs12000, rs1150724, rs1150722, rs3800324, and rs1997660), was significantly associated with schizophrenia (P = 6.60E-05). We also performed a combined study of this replication sample and the first-stage GWAS sample. The combined study revealed that rs12000 and rs1150722 were still strongly associated with schizophrenia (rs12000: allele G>A, P combined = 0.0019, OR = 0.81; rs1150722: allele G>A, P combined = 3.00E-04, OR = 0.61). These results support our findings that locus 6p21-p22.1 is significantly associated with schizophrenia in the Chinese Han population and encourage further studies of the functions of these genetic factors.

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“…The same group focused on pharmacogenomics of antipsychotic drugs as related to polymorphisms of DRD2 and SLC6A4 (Vijayan et al, 2007, 2009). A research group from north Bengal worked primarily on HLA-G and HLA Class I gene markers (Debnath & Chaudhuri, 2006; Singh et al, 2011). The same group also reported decreased serum levels of the interleukins IL-2 and IL-6 levels in SZ patients (Singh et al, 2009).…”

Section: Ongoing Work In Indiamentioning

confidence: 99%

“…These interactions have important medical implications and suggest that targeting the appropriate pathogens may have dramatic effects on the incidence and progression of SZ (Yolken & Torrey, 2008). A large number of cytokine- and chemokine-related genes ( CCR5, CSF2RA, CSF2RB, IL1B, IL1RN, IL2, IL3, IL3RA, IL4, IL10, IL10RA, IL12B, IL18, IL18R1, IL18RAP, LTA, TNF ) and major histocompatibility complex antigens ( HLAA10, HLA-B, HLA-DRB1 ) have been implicated in SZ and interact with a range of infective agents (Duan et al, 2010; Jones et al, 2005; Miuller & Schwarz, 2007; Nawa & Takei, 2006; Pert, 1988; Saetre et al, 2007; Shirts et al, 2006, 2007; Wright et al, 2001). …”

Section: How Can Gene Mapping Studies Assist the Practising Clinician?mentioning

confidence: 99%

Genetics of schizophrenia from a clinicial perspective

Kukshal

Thelma

Nimgaonkar

et al. 2012

International Review of Psychiatry

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Schizophrenia (SZ) is a common disorder that runs in families. It has a relatively high heritability, i.e. inherited factors account for the major proportion of its etiology. The high heritability has motivated gene mapping studies that have improved in sophistication through the past two decades. Belying earlier expectations, it is now becoming increasingly clear that the cause of SZ does not reside in a single mutation, or even in a single gene. Rather, there are multiple DNA variants, not all of which have been identified. Additional risk may be conferred by interactions between individual DNA variants, as well as ‘gene-environment’ interactions. We review studies that have accounted for a fraction of the heritability. Their relevance to the practising clinician is discussed. We propose that continuing research in DNA variation, in conjunction with rapid ongoing advances in allied fields, will yield dividends from the perspective of diagnosis, treatment prediction through pharmacogenetics, and rational treatment through discoveries in pathogenesis.

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Study of HLA Class I gene in Indian schizophrenic patients of Siliguri, West Bengal

Cited by 10 publications

References 50 publications

An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

Replication of Association between Schizophrenia and Chromosome 6p21-6p22.1 Polymorphisms in Chinese Han Population

Genetics of schizophrenia from a clinicial perspective

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