The current cholera outbreak in the Federal Democratic Republic of Ethiopia began in August 2022. As of April 2024, active outbreaks had been recorded in most regions of the country, including: Amhara; Dire Dawa; Harari; Oromia; Southern Nations, Nationalities and Peoples’ Region (SNNPR); Somali and Tigray. This brief has been developed to support response efforts by exploring the social and structural determinants and community dynamics of cholera infection and mortality in Ethiopia. Socio-cultural and epidemiological information, academic and grey literature and consultations with cholera response experts in Ethiopia have been used to develop the brief.