Study of Homologous Autoimplantation Therapy for Treatment of Multiple Warts in Patients Attending the Dermatology out Patient Department

Abstract

Introduction: Warts are benign tumours that commonly involve skin and other epithelial tissues. There is no single treatment modality that is 100% effective. In multiple warts, especially on face, palms, and soles destructive procedure are inappropriate and impractical. Homologous autoimplantation is a simple technique, which helps in inducing cell mediated response, causing clearance of warts. Aims and objectives: To evaluate the effect of homologous autoimplantation therapy in treatment of multiple warts. To study the untoward effects of this treatment. Material and methods: A total of 49 patients of viral warts were included in study. Homologous autoimplantation of wart was done and regular follow up was done to see the result. Results: Out of 49 patients, in 24 patients there was good response, 14 showed moderate response, 5 showed poor response and in 6 patients there was no response. Conclusion: Homologous autoimplantation is an easy, minimally invasive technique which clears multiple, recurrent and recalcitrant warts.

Role of autoinoculation in the management of cutaneous warts: a comparison study with 100% tricholoroacetic acid application

“…Gugle et al reported least response in plane warts (34.49% reduction in mean number of warts). 8 In contrast to our findings, Ghosh and Maplestone reported cure in 9 of 12 patients with plane warts and significant improvement in those who were not cured. 11 Gugle et al reported maximum response in filiform warts (93.28% reduction in mean number) which contrasts the findings of our study (13.11% reduction in the mean number).…”

“…Infection at the autoinoculation site has been reported in 2.4-6.12% cases in other studies. 4,7,8 One patient complained of persistent pain at the autoinoculation site which subsided after 2-3 weeks. Two patients had persistent erythema without pain at the autoinoculation site which resolved after 5-6 weeks.…”

“…Complete clearance has been reported as 20-74.1% in various studies on autoinoculation. [2][3][4][5][6][7][8][9][10][11] We found improvement with autoinoculation therapy as early as 2 weeks. Other workers have reported improvement occurring earliest at 3 weeks and 4 weeks.…”

“…The findings of our autoinoculation group are similar to that of Nischal et al 4 Several studies have reported higher partial clearance rates (22.64-53.06%), while others have not reported partial clearance. 2,3,[5][6][7][8] Infection with antigenically heterogeneous HPV types in some cases, could account for partial clearance, and it is possible that complete rather than partial clearance was seen in our study because we re-inoculated patients at follow ups. An unusual finding in our study was that both patients showing partial clearance had only a single wart remaining which persisted after a further 2 months of observation in both the patients without appearance of new lesions.…”

“…11 Gugle et al reported maximum response in filiform warts (93.28% reduction in mean number) which contrasts the findings of our study (13.11% reduction in the mean number). 8 However, percentage of patients showing complete, partial and failure to respond for each type of wart was not reported.…”