Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya, Hardik; Patel, Amit A.; Patel, Dipal; Kaushal, Ashish; Vijay, D. G.

doi:10.1007/s12291-012-0294-8

Cited by 13 publications

(18 citation statements)

References 32 publications

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“…There was significant correlation seen between the age of the patient and ER (p = 0.000) & PR (p = 0.000) expression in present study. Studies by Dodiya H et al [19] and Ghosh S et al [20] showed similar results. Significant correlation was also observed between age of the patient and HER2/neu expression (p = 0.000), similar to studies conducted by Ramic S et al [21] and Ganesan M et al [22] Axillary Lymph Node Status 38% patients had axillary lymph nodes positive for metastasis.…”

Section: Agesupporting

confidence: 56%

Immunohistochemical Profile of Infiltrating Ductal Carcinoma Breast- Prognostic and Therapeutic Use

Chand¹,

Kumar²,

Singla³

et al. 2017

jemds

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BACKGROUND Breast carcinoma is the most common malignant tumour and the leading cause of death in women. Various prognostic and predictive factors are used in the management of breast cancer. Oestrogen receptor (ER), progesterone receptor (PR) & human epidermal growth receptor (HER2/neu) are prognostic as well as predictive factors. The aim of the present study was conducted to evaluate ER, PR & HER2/neu expression in invasive ductal carcinoma of the breast (not otherwise specified) by immunohistochemistry to explore the correlation of these markers to each other, as well as to various clinicopathological parameters like age of patient, histological grade, tumour size and lymph node metastasis. MATERIALS AND METHODS 100 cases of infiltrating ductal carcinoma (NOS) were taken. Slides were prepared from paraffin blocks containing cancer tissue of these patients & immunohistochemical staining was done for ER, PR, and HER2/neu expressions. Interpretation of expressions done using Allred scoring system for ER/PR & ASCO/CAP guidelines for HER2/neu. Statistical analysis was done to determine the statistical significance by applying chi-square test. RESULTS In our study, mean age was 55.28 years. Average tumour size was 4.3 cm & majority of tumours were grade II. 38 patients had axillary lymph nodes positive for metastasis. 58 cases were both ER & PR positive and 37 cases ER/PR negative. Only 7 were HER2/neu positive & 93 were HER2/neu negative. Only 2 cases were both ER as well as HER2/neu positive, 32 cases were both ER & HER2/neu negative. 66 cases showed different expressions of ER & HER/neu. ER & PR correlated significantly with age, tumour size, and tumour grade; whereas HER2/neu correlated significantly with age & tumour size only. No association was seen with axillary lymph node metastasis. ER and PR expression correlated with each other, but none was correlated with HER2/neu. CONCLUSION Assessment of hormone receptors for clinical management of a breast cancer patient is strongly recommended to provide prognostic information and therapeutic options.

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Section: Agesupporting

confidence: 56%

Immunohistochemical Profile of Infiltrating Ductal Carcinoma Breast- Prognostic and Therapeutic Use

Chand¹,

Kumar²,

Singla³

et al. 2017

jemds

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“…[38] In presnt study, there was seen significant correlation tumor grade with ER(p value=0.003) & PR(p value=0.031), study done by Thoreson S et al, [39] Onitilo AA et al, [14] and Dodiya H et al showed similar results. [29] No significant association was seen between tumor grade and HER2/neu expression (p value=0.298) in present study. Study conducted by Naeem M et al, [40] and Dodiya H et al showed similar results.…”

Section: Subtype4contrasting

confidence: 61%

“…In the present study, there was seen significant correlation between age of the patient and ER (p value=0.000), PR (p value=0.000) and HER2/neu (p value=0.000) expression in present study. Studies by Desai SB et al, [28] Dodiya H et al, [29] Thang VH et al, [30] and Ganesan M et al, [31] showed similar results. The majority of receptors positive cases were postmenopausal in our study.…”

Section: Subtype4mentioning

confidence: 54%

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Immunohistochemical Profile of Infiltrating Ductal Carcinoma Breast (Not Otherwise Specified) - A Study Of 100 Cases

Kaur¹,

Kaur²,

Singh³

et al. 2017

Ann. Int. Med. Den.Res.

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Background: Breast carcinoma is the most common malignant tumor. Infiltrating ductal carcinoma-not otherwise specified is the most common histological pattern of breast cancer. Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2/neu) are immunohistochemical prognostic and predictive markers. AIM: The aim of the study was to explore the correlation of these immunohistochemical markers to each other, age of the patient, histological grade, menopausal status, tumor size, lymph node metastasis and to find the frequency of occurrence of the four immunohistochemical sub-types of breast cancer. Methods: In our cross-sectional study, we included patients coming to the department of Pathology. Paraffin sections from 100 cases diagnosed with infiltrating ductal carcinoma (NOS) were analyzed by immunohistochemical means for ER, PR and HER2/neu expressions and collected data was analyzed statistically by chi-square method. Results: The mean age of the patients was 55.

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“…Breast cancer is the commonest cancer in women worldwide, including Nigeria [1]. The cancer is also associated with a high mortality, especially when the patient presents at a late stage and has a high grade disease [2].…”

Section: Introductionmentioning

confidence: 99%

Her-2/neu overexpression in breast cancers in patients of West African extraction seen in Lagos state University Teaching hospital, Nigeria

Sanni

Popoola

Ibrahim

et al. 2019

European Journal of Surgical Oncology

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Introduction: Her-2/neu is one of the most important molecular markers of breast cancer. Overexpression of Her-2/neu as evaluated by immunohistochemistry is necessary in the management of breast cancers. This study was performed to determine the proportion of expression of the biomarker amongst breast cancer patients who presented in our 'one-stop breast cancer unit' using automated immunohistochemistry. Materials and methods: Automated immunohistochemical analysis of 107 newly diagnosed breast cancer patients was done for expression of Her-2/neu, between 1st April, 2016 and 30th September, 2018. The data was analyzed using SPSS version 25 for windows and Microsoft excel, 2013. Results: Her-2/neu was overexpressed in 30.1% patients, and it shows no correlation with age and histological grade of the disease. Conclusion: There is overexpression of Her-2/neu in our local setting, and this observation is very relevant to any therapeutic decisions and management of these patients.

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Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Cited by 13 publications

References 32 publications

Immunohistochemical Profile of Infiltrating Ductal Carcinoma Breast- Prognostic and Therapeutic Use

Immunohistochemical Profile of Infiltrating Ductal Carcinoma Breast- Prognostic and Therapeutic Use

Immunohistochemical Profile of Infiltrating Ductal Carcinoma Breast (Not Otherwise Specified) - A Study Of 100 Cases

Her-2/neu overexpression in breast cancers in patients of West African extraction seen in Lagos state University Teaching hospital, Nigeria

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