Study of human cortical bone and demineralized human cortical bone viscoelasticity

Fois, Magali; Lamure, A.; Fauran, M. J.; Lacabanne, C.

doi:10.1002/1097-4628(20010401)79:14<2527::aid-app1061>3.0.co;2-j

Cited by 16 publications

(11 citation statements)

References 25 publications

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“…27c, the highest values across both strains are also found close to the endosteal surface, with the values decreasing as the indenter moves away from the endosteal edge. Since hydrated bone owes its remarkable viscoelasticity to the collagen fibrils in the bone matrix [165,172], the above trend supports a direct relationship between larger viscoelastic response and lower mineral-to-matrix ratio (a higher collagen content). Thus the decrease in the values of away from the endosteal edge is indicative of the higher degree of maturity of the bone in this region.…”

Section: Comparing With Micro-pillar Compression Experimentsmentioning

confidence: 61%

Spherical nanoindentation stress–strain curves

Pathak

Kalidindi

2015

Materials Science and Engineering: R: Reports

300

176

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Although indentation experiments have long been used to measure the hardness and Young's modulus, the utility of this technique in analyzing the complete elasticplastic response of materials under contact loading has only been realized in the past few years-mostly due to recent advances in testing equipment and analysis protocols. This paper provides a timely review of the recent progress made in this respect in extracting meaningful indentation stress-strain curves from the raw datasets measured in instrumented spherical nanoindentation experiments. These indentation stress-strain curves have produced highly reliable estimates of the indentation modulus and the indentation yield strength in the sample, as well as certain aspects of their post-yield

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Section: Comparing With Micro-pillar Compression Experimentsmentioning

confidence: 61%

Spherical nanoindentation stress–strain curves

Pathak

Kalidindi

2015

Materials Science and Engineering: R: Reports

300

176

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“…Both FTIR (Courtland et al, 2008) and Raman Spectroscopy (Miller et al, 2007; Patel, 2007; Pathak, 2009) studies have demonstrated that the mineral-to-matrix ratio increase as bone matures from the endosteal surface to more intracortical regions. Since hydrated bone owes its remarkable viscoelasticity to the collagen fibrils in the bone matrix (Fois et al, 2001; Jepsen et al, 2001), the trend towards larger tan delta data near the endosteal surface support a direct relationship between larger viscoelastic response and lower mineral-to-matrix ratio, and the decrease in the values of tan δ away from the endosteal edge is indicative of the higher degree of maturity of the bone in this region. However, owing to the fact that these spectroscopic methods are applicable only on dry samples, the exact composition at the indent locations in the wet samples could not be measured in this study.…”

Section: Discussionmentioning

confidence: 93%

Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation

Pathak

Swadener

Kalidindi

et al. 2011

Journal of the Mechanical Behavior of Biomedical Materials

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This study demonstrates a novel approach to characterizing hydrated bone’s viscoelastic behavior at the lamellar length scales using dynamic indentation techniques. We studied the submicron-level viscoelastic response of bone tissue from two different inbred mouse strains, A/J and B6, with known differences in whole bone and tissue-level mechanical properties. Our results show that bone having a higher collagen content or a lower mineral-to-matrix ratio demonstrates a trend towards a larger viscoelastic response. When normalized for anatomical location relative to biological growth patterns in the antero-medial (AM) cortex, bone tissue from B6 femora, known to have a lower mineral-to-matrix ratio, is shown to exhibit a significantly higher viscoelastic response compared to A/J tissue. Newer bone regions with a higher collagen content (closer to the endosteal edge of the AM cortex) showed a trend towards a larger viscoelastic response. Our study demonstrates the feasibility of this technique to be used to study local composition-property relationships in bone. Further, this technique of viscoelastic nanoindentation mapping of the bone surface at these submicron length scales is shown to be highly advantageous in studying sub-surface features, such as porosity, of wet hydrated biological specimens, which are difficult to identify using other methods.

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“…However, the third component, water, is less well-understood. Water is clearly an integral part of the structure (Nomura et al, 1977;Pineri et al, 1978;Robinson and Elliot, 1957;Robinson, 1979) and plays an important role in the mechanical properties of bone and teeth (Currey, 1990;Yamashita et al, 2002;Kishen and Asundi, 2005;Fois et al, 2001;Fernandez-Seara et al, 2004).…”

Section: Introductionmentioning

confidence: 99%