Study of hydrogen bonding in ethanol-water binary solutions by Raman spectroscopy

Li, Fabing; Men, Zhiwei; Li, Shuo; Wang, Shenghan; Li, Zhanlong; Sun, Chenglin

doi:10.1016/j.saa.2017.08.077

Cited by 109 publications

(60 citation statements)

References 27 publications

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“…The wavenumber of the CÀ S stretching vibration of MUA nicely matches the value expected for the Gauche conformation of the molecule adsorbed on a silver surface. [34,35] Finally, in order to take into account possible intensity variations between SERS spectra, the 885 cm À 1 band of ethanol, assigned to skeletal CCO stretching or CH 3 rocking vibrations, [36][37] was chosen as the internal reference. Even though the bulk Raman signal of ethanol is very weak in regions void of AgNWs under evanescent field excitation, it can be detected easily in little stacks of AgNWs probably due to its SERS enhancement ( Figure S9 in SI).…”

Section: Resultsmentioning

confidence: 99%

Efficient Passivation of Ag Nanowires with 11‐Mercaptoundecanoic Acid Probed Using In Situ Total‐Internal‐Reflection Surface‐Enhanced Raman Scattering Spectroscopy

et al. 2019

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A promising passivation strategy of one class of Ag nanostructures of high interest for optoelectronics, namely Ag nanowires (AgNWs), with 11‐mercaptoundecanoic acid (MUA) is described. Combining XPS, electron microscopy and original in‐situ total‐internal‐reflection (TIR) surface‐enhanced Raman scattering (SERS) spectroscopic measurements, the substitution of polyvinylpyrrolidone (PVP) molecules on as‐synthesized PVP‐coated AgNWs by their MUA counterparts is clearly demonstrated. The relevance of the SERS approach to examine the anchoring of the MUA onto the silver surface of specific AgNWs with pentagonal cross‐sections is supported by FDTD simulations. In particular, the TIR‐SERS technique reveals that the PVP‐MUA substitution process can be divided into two main steps, namely (i) the desorption of PVP molecules associated with the anchoring of MUA molecules via the formation of Ag−OOC and Ag−S bonds (accomplished within 40 min), and (ii) the subsequent reorientation of MUA molecules to form only Ag−S bonds (finished in 90 min). The resulting passivation of AgNWs with MUA significantly improves their resistance to corrosion, which is crucial for future commercial applications.

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Section: Resultsmentioning

confidence: 99%

Efficient Passivation of Ag Nanowires with 11‐Mercaptoundecanoic Acid Probed Using In Situ Total‐Internal‐Reflection Surface‐Enhanced Raman Scattering Spectroscopy

et al. 2019

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“…It is likely that our observed deviation from the true methanol mass fraction is a result of real changes in the mixture. Indeed, it has been shown that water-methanol [10,12,21,22] and waterethanol [22][23][24] mixtures form different water-methanol complexes at different concentrations, and that these complexes display fundamentally different Raman spectra from that of the pure compound. Thus, fundamentally, the spectrum of a water-methanol mixture cannot be perfectly modeled as a linear combination of the spectra of the two components.…”

Section: Accuracymentioning

confidence: 99%

Rapid, accurate, and precise concentration measurements of a methanol–water mixture using Raman spectroscopy

et al. 2018

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Here we design, construct, and characterize a compact Raman-spectroscopy-based sensor that measures the concentration of a water-methanol mixture. The sensor measures the concentration with an accuracy of 0.5% and a precision of 0.2% with a 1 second measuring time. With longer measurement times, the precision reaches as low as 0.006%. We characterize the long-term stability of the instrument over an 11-day period of constant measurement, and confirm that systematic drifts are on the level of 0.02%. We describe methods to improve the sensor performance, providing a path towards accurate, precise, and reliable concentration measurements in harsh environments. This sensor should be adaptable to other water-alcohol mixtures, or other small-molecule liquid mixtures.

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“…Ethanol's cytotoxic ability is due to the fact ethanol molecules are very-small and polar; thus, tagging ethanol with a radio-opaque or fluorescent probe to monitor its location was deemed impractical for this study as it would affect the transport of ethanol through tissues. Ethanol does, however, produce a distinct signal with Raman spectroscopy (27,28) which was utilized to monitor the release kinetics of ethanol through tumor tissue. To monitor the spatial distribution of EC-ethanol a fluorescent powder, fluorescein, was mixed with ECethanol to monitor the approximate location of the injectate in vivo and ex vivo.…”

Section: Introductionmentioning

confidence: 99%

Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model

Nief

Morhard

Chelales

et al. 2020

Preprint

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Focal tumor ablation with ethanol could provide benefits in low-resource settings because of its low overall cost, minimal imaging technology requirements, and acceptable clinical outcomes.Unfortunately, ethanol ablation is not commonly utilized because of a lack of predictability of the ablation zone, caused by inefficient retention of ethanol at the injection site. To create a predictable zone of ablation, we have developed a polymer-assisted ablation method using ethyl cellulose (EC) mixed with ethanol. EC is ethanol-soluble and water-insoluble, allowing for EC-ethanol to be injected as a liquid and precipitate into a solid, occluding the leakage of ethanol upon contact with tissue. The aims of this study were to compare the 1) safety, 2) release kinetics, 3) spatial distribution, 4) necrotic volume, and 5) overall survival of EC-ethanol to conventional ethanol ablation in a murine breast tumor model. Non-target tissue damage was monitored through localized adverse events recording, ethanol release kinetics with Raman spectroscopy, injectate distribution with in vivo imaging, target-tissue necrosis with NADH-diaphorase staining, and overall survival by proxy of tumor growth. EC-ethanol exhibited decreased localized adverse events, a slowing of the release rate of ethanol, more compact injection zones, 5-fold increase in target-tissue necrosis, and longer overall survival rates compared to the same volume of pure ethanol. A single 150 µL dose of 6% EC-ethanol achieved a similar survival probability rates to six daily 50 µL doses of pure ethanol used to simulate a slow-release of ethanol over 6 days. Taken together, these results demonstrate that EC-ethanol is safer and more effective than ethanol alone for ablating tumors. Graphical Abstract:The inclusion of ethylcellulose limits extra-tumoral leakage of ethanol and increases the target-tissue ablation.

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Study of hydrogen bonding in ethanol-water binary solutions by Raman spectroscopy

Cited by 109 publications

References 27 publications

Efficient Passivation of Ag Nanowires with 11‐Mercaptoundecanoic Acid Probed Using In Situ Total‐Internal‐Reflection Surface‐Enhanced Raman Scattering Spectroscopy

Efficient Passivation of Ag Nanowires with 11‐Mercaptoundecanoic Acid Probed Using In Situ Total‐Internal‐Reflection Surface‐Enhanced Raman Scattering Spectroscopy

Rapid, accurate, and precise concentration measurements of a methanol–water mixture using Raman spectroscopy

Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model

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