2020
DOI: 10.1080/20013078.2020.1795364
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Study of immune‐tolerized cell lines and extracellular vesicles inductive environment promoting continuous expression and secretion of HLA‐G from semiallograft immune tolerance during pregnancy

Abstract: An immune reaction is a protector of our body but a target to be overcome for all non-self-derived medicine. Extracellular Vesicles (EVs), noted as a primary alternative to cell therapy products that exhibit immune rejection due to mismatching-major histocompatibility complex (MHC), were discovered to have excellent curative effects through the delivery of various biologically active substances. Although EVs are sure to incur immune reaction by immunogenicity due to alloantigens from their parental cells, thei… Show more

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Cited by 14 publications
(24 citation statements)
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“…Human amniotic mesenchymal stem cells (hAM-MSCs) and human umbilical cord blood mesenchymal stem cells (UCB-MSCs) were purchased from ScienCell (Carlsbad, CA, USA). Human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs) were established as described in the previous study [22]. These MSCs were maintained in DMEM medium (Welgene, Republic of Korea) supplemented with 100 U/mL of penicillin, 100 μg/mL of streptomycin, and 10% heat-inactivated FBS.…”
Section: Cell Lines and Culturementioning
confidence: 99%
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“…Human amniotic mesenchymal stem cells (hAM-MSCs) and human umbilical cord blood mesenchymal stem cells (UCB-MSCs) were purchased from ScienCell (Carlsbad, CA, USA). Human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs) were established as described in the previous study [22]. These MSCs were maintained in DMEM medium (Welgene, Republic of Korea) supplemented with 100 U/mL of penicillin, 100 μg/mL of streptomycin, and 10% heat-inactivated FBS.…”
Section: Cell Lines and Culturementioning
confidence: 99%
“…An in vivo-like culture condition for inducing immune-tolerized cell lines was applied using temperature change, pH, and circulation conditions established in the previous study [22]. In summary, temperature change between 36.0 ℃ and 37.0 ℃ with a five or six-day cycle and an acidic pH of 6.2 to 6.8 by hyaluronic acid (HA)-based matrix were applied to induce the secretion of various pregnancy-related hormones as shown in Figure 2C.…”
Section: In Vivo-like Temperature Change Ph and Circulation Conditionsmentioning
confidence: 99%
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“…Progesterone's effect on different cell types and trophoblast, like the newly described variety of trophoblast expressing HLA-G, is unknown [113]. However, in this case, the critical element modulates inhibitory signals through the KIR receptors, which can be crucial for embryo implantation and successful pregnancy.…”
Section: Progesteronementioning
confidence: 99%