Study of immunohistochemical expression of VEGF and its association with HPV E6 And E7 oncoproteins in oral and oropharyngeal squamous cell carcinoma

Sharma, Ankita; Agarwal, Kiran; Agarwal, Savita; Kumar, Shilpa; Bharti, Anju

doi:10.1093/annonc/mdx665.018

Cited by 3 publications

(2 citation statements)

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“…51 However, the study of immunohistochemical expression of VEGF with regard to HPV status in oral and oropharyngeal cell carcinoma shows no significant difference in VEGF expression to HPV status. 52 Further analysis of VEGF expression with regard to HPV status needed to be performed using more robust detection method such as ELISA on OSCC samples to validate the VEGF expression in HPV-related OSCC.…”

Section: Vegf/vegfr and Hpv-related Osccmentioning

confidence: 99%

A Review on the Role of Vascular Endothelial Growth Factor Receptors in Human Papillomavirus-related Oral Squamous Cell Carcinoma

Zawawi

Aziz

Nafi

et al. 2023

imjm

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Oral squamous cell carcinoma (OSCC) is a neoplasm at the epithelial lining of the oral cavity that is prevalent worldwide. Smoking tobacco and consumption of alcohol are the main risk factors for OSCC. However, human papillomavirus (HPV) could also be an aetiological factor for OSCC. Transmission through urogenital contact increases the risk of developing OSCC, especially in developed countries. HPV-related cancer displays different pathogenesis and clinical outcomes. HPV through its oncogene E6 and E7 play a critical role in carcinogenesis by disrupting the DNA repair mechanism and cell cycle. Increased expression of VEGF ligand in HPV-related cancer has been reported in numerous studies. In OSCC, VEGFRs, i.e., VEGFR-1, VEGFR-2, and VEGFR-3, are overexpressed, with a higher expression on VEGFR-2. In HPV-infected OSCC, HPV is associated with VEGF expression. However, VEGFRs show no such association. This review highlights the possible role of angiogenesis in the progression of HPV-related OSCC. Also, it discusses how VEGF/VEGFR regulated the angiogenic activity caused by the HPV infection. Data on VEGF/VEGFR associated with HPV status is limited, and their role in OSCC progression remains unclear. Elucidating the mechanism of angiogenesis in HPV-associated OSCC may help develop strategies for OSCC-targeted therapy.

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Section: Vegf/vegfr and Hpv-related Osccmentioning

confidence: 99%

A Review on the Role of Vascular Endothelial Growth Factor Receptors in Human Papillomavirus-related Oral Squamous Cell Carcinoma

Zawawi

Aziz

Nafi

et al. 2023

imjm

View full text Add to dashboard Cite

show abstract

“…Data show that the 5-year survival rate of OSCC is only 50 to 60%, and some patients have advanced disease and local metastasis at the time of diagnosis, which is not conducive to clinical treatment (4,5). A previous study stated that the patients with advanced oral cancer had a poor 3-year survival rate (6). At present, the most effective treatment for patients with locally advanced OSCC suitable for resection is comprehensive treatment based on radical surgery (7).…”

Section: Introductionmentioning

confidence: 99%

Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis

Feng

Shao

2020

Oncol Lett

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Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis were investigated. Fifty patients with oral cancer treated in the Affiliated Stomatological Hospital of Jiamusi University from March 2014 to January 2016 were enrolled in the study group, while 50 healthy subjects receiving physical examinations during the same period were enrolled in the control group. Serum expression of miR-223-3p was quantified by RT-qPCR. The diagnostic value of miR-223-3p in oral cancer was analyzed by the receiver operating characteristic (ROC) curve. Expression of miR-223-3p before and after treatment was compared. The study group was divided into the remission and the non-remission group based on the treatment outcome to analyze the predictive value of miR-223-3p. Patients were followed up for 3 years. Cox regression analysis was performed to analyze the independent prognostic factors. The relative serum miR-223-3p level was lower in the study than in the control group (P<0.001). Expression of miR-223-3p was significantly higher after treatment than before (P<0.05). Spearman's correlation analysis indicated that miR-223-3p expression before treatment gradually increased with the improvement of treatment outcome (r= 0.617, P<0.001). The miR-223-3p level was markedly higher in the remission than in the non-remission group (P<0.05). The area under the ROC curve of miR-223-3p was 0.797. Multivariate Cox regression analysis demonstrated that the degree of differentiation [HR: 11.862 (95% CI: 2.730-51.547)] and miR-223-3p [HR: 3.489 (95% CI: 1.447-8.413)] were independent prognostic factors. The 3-year survival of patients with high differentiation and high miR-223-3p expression was significantly higher than that of patients with poor differentiation and low miR-223-3p expression (P<0.05). In conclusion, miR-223-3p expression is low in oral cancer, and it shows potential for predicting the efficacy and prognosis of patients with oral squamous cell carcinoma (OSCC) after TPF regimen.

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A potential association between mutations in the iNOS cDNA 3′ stretch and oral squamous cell carcinoma - A preliminary study

2018

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Study of immunohistochemical expression of VEGF and its association with HPV E6 And E7 oncoproteins in oral and oropharyngeal squamous cell carcinoma

Cited by 3 publications

References 0 publications

A Review on the Role of Vascular Endothelial Growth Factor Receptors in Human Papillomavirus-related Oral Squamous Cell Carcinoma

A Review on the Role of Vascular Endothelial Growth Factor Receptors in Human Papillomavirus-related Oral Squamous Cell Carcinoma

Changes of serum miR-223-3p in patients with oral cancer treated with TPF regimen and the prognosis

A potential association between mutations in the iNOS cDNA 3′ stretch and oral squamous cell carcinoma - A preliminary study

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