Study of Impact of Birth Asphyxia on Thyroid Hormone in Newborn.

Abstract

Aim and Objective: Study of the Impact of birth asphyxia on thyroid hormone in newborns.Methods: It was a prospective case-control study conducted at SCB Medical College, Department of Pediatrics. For the study, a total of 200 full-term newborns were assigned of which 100 asphyxiated newborns were taken as cases and 100 healthy newborns as a control group. Sarnat and Sarnat staging is used to classify the severity of birth asphyxia. Blood samples were collected at 18 to 24 hours of age for thyroid hormone level estimation.Results: Out of 100 cases, 33% were HIE stage 1, 43% were HIE stage 2, and 24% were HIE stage 3. The mean value of T3, T4, and TSH was lower at 18 to 24 hours of age. Conclusion:The mean T3, T4, and TSH level at 18 to 24 hours of asphyxiated newborn was significantly lower than the control group.Recommendation: More studies need to be done with a larger sample size in different regions of India and investigate the prevalence of thyroid hypoxic-ischemic encephalopathy and its association with morbidity.