Study of interaction between metal ions and quercetin

Castilho, Taiane S. de; Matias, Tatiane Brescovites; Nicolini, Keller Paulo; Nicolini, Jaqueline

doi:10.1016/j.fshw.2018.08.001

Cited by 42 publications

(31 citation statements)

References 28 publications

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“…Like carotenoids, flavonoids also possess an antioxidant activity and function as a free radical scavenger and a chelator of transition metal ions such as iron, a key metal in the generation of ROS through the Fenton reaction (Murota & Terao, 2003). Studies investigating polyphenols such as quercetin have demonstrated their ability to effectively inhibit lipid peroxidation in the shrimp muscle (León, Wasielesky, & Monserrat, 2018) and also to chelate transition metal ions (Castilho, Matias, Nicolini, & Nicolini, 2018). In addition to their antioxidant properties, polyphenols exert several other specific biological actions such as modulating the activity of a wide range of enzymes and cellular receptors and interfering the activity and expression of various cell membrane transporters (Keating, Calhau, Faria, & Martel, 2018).…”

Section: Introductionmentioning

confidence: 99%

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

et al. 2020

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This study investigated the effects of the inclusion of Mauritia flexuosa fruit pulp in the diet on the growth performance, economic benefit, muscle composition, total contents of carotenoids and flavonoids, chromaticity parameters, total antioxidant capacity, and lipid peroxidation in the hepatopancreas and muscle of the juvenile shrimp Litopenaeus vannamei (weighing 1.26 ± 0.023 g). Five diets (37% protein, 10% lipid) consisting of 0 (control), 1.25%, 2.50%, 5.00% and 10.00% (w/w) M. flexuosa fruit pulp were formulated and provided to the shrimps (n = 50 per tank, treatments in triplicate) for 31 days. Results showed that there were no significant differences between the treatments in terms of the growth capacity, chromaticity parameters, muscle composition and total flavonoid content of shrimps (p > .05). However, the carotenoid content in the muscle and hepatopancreas of the shrimps was significantly increased due to the dietary carotenoids present in M. flexuosa fruit pulp (p < .05). This increase in the carotenoid content directly favoured the increase in the antioxidant capacity in the hepatopancreas and muscle of the shrimps (R2 = 0.99 and R2 = 0.97 respectively; p < .05). There was also a direct relationship between the carotenoid content and the decrease in lipid peroxidation in the hepatopancreas (R2 = 0.90; p < .05). The feed cost kg−1 in terms of weight gain and protein production decreased with the inclusion of high levels of M. flexuosa fruit pulp, reaching 8.11% and 18.76% of cost reduction, respectively, with the addition of 5.00% of M. flexuosa fruit pulp. Therefore, the inclusion of M. flexuosa fruit pulp in the diets of shrimp can increase the carotenoid content and the antioxidant capacity in the hepatopancreas and muscle, reduce lipid peroxidation in the hepatopancreas, and probably provide economic benefits for the rearing of juvenile shrimps.

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Section: Introductionmentioning

confidence: 99%

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

et al. 2020

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“…This could be related with the capability of quercetin to chelate various metal ions, such as Ca +2 and Mg +2 (ions present in SIF stock solution). The formation of these complexes normally occurs for flavonoids like quercetin and not in catechins, like EGCG [26][27][28]. More studies are needed to be conclusive, however this is outside of the scope of the current investigation.…”

Section: Plos Onementioning

confidence: 87%

Interaction of quercetin and epigallocatechin gallate (EGCG) aggregates with pancreatic lipase under simplified intestinal conditions

et al. 2020

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Diets rich in flavonoids have been related with low obesity rates, which could be related with their potential to inhibit pancreatic lipase, the main enzyme of fat assimilation. Some flavonoids can aggregate in aqueous medium suggesting that the inhibition mechanism could occur on both molecular and colloidal levels. This study investigates the interaction of two flavonoid aggregates, quercetin and epigallocatechin gallate (EGCG), with pancreatic lipase under simplified intestinal conditions. The stability and the morphology of these flavonoid aggregates were studied in four different solutions: Control (water), salt, low lipase concentration and high lipase concentration. Particles were found by optical microscopy in almost all the solutions tested, except EGCG-control. The results show that the precipitation rate decreases for quercetin and increases for EGCG in salt solution and that lipase stabilize quercetin aggregates. In addition, both flavonoids were shown to precipitate together with pancreatic lipase resulting in a sequestering of the enzyme.

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“…Some of these compounds have been demonstrated to modify oxidative stress-related pathways altered by environmental toxicants including nickel [66,67]. Also, quercetin forms complex with nickel and accelerate its removal from the body [68].…”

Section: Discussionmentioning

confidence: 99%

Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

et al. 2020

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Background: Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sativa (ENS) on nickel chloride (NiCl 2)-induced hepato-renal damage was evaluated by monitoring biochemical and oxidative stress markers. Additionally, the antioxidant capacity and phytochemical constituents of ENS were quantified using HPLC and GC-MS. Result: NiCl 2 significantly increased (p < 0.05) aspartate aminotransferase, creatinine, sodium ion, chloride ion and malondialdehyde levels, while antioxidant enzymes were decreased in the organs except for kidney glutathione-Stransferase when compared to the control. However, ENS exerted inhibitory effect against NiCl 2 toxicity in both organs by reversing the biomarkers towards control levels. ENS has a high antioxidant capacity and is rich in antioxidants including gallic acid, quercetin, eucalyptol and levomenthol that may have accounted for the improvement of hepato-renal health in co-exposed rats. Conclusion: Our result suggests that amelioration of nickel chloride-induced hepato-renal pathology by ethanol extract of Nigella sativa was related to its antioxidant properties. Therefore, Nigella sativa could be valuable in the management of nickel-induced toxicity.

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Study of interaction between metal ions and quercetin

Cited by 42 publications

References 28 publications

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

Interaction of quercetin and epigallocatechin gallate (EGCG) aggregates with pancreatic lipase under simplified intestinal conditions

Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

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