Study of interferon-γ-inducible protein-10 levels during antiviral therapy of hepatitis C patients with sofosbuvir plus ribavirin and interferon in Menoufia hospitals

El-Hendawy, Ghada R; Salama, Ahmed A; El-Shayb, El-Sayed I; Elhosseny, Nancy R Ahmed

doi:10.4103/mmj.mmj_555_16

Cited by 2 publications

(4 citation statements)

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Section: Discussionsupporting

confidence: 93%

“…Regarding IL-12 levels, in dual therapy group, there was a statistically significant difference between levels observed after 8 weeks of treatment and those found 3 months after treatment completion, while in triple therapy, comparable IL-12 levels were found at both timepoints. Similar findings were reported by El-Hendawy et al, [55] and agrees with the findings of Carlin et al [56] Logistic regression analysis was performed to study the independent predictors for treatment failure. We found that only AST levels at baseline and the T/T variant of the IL28B gene were independently associated with treatment failure.…”

Section: Discussionsupporting

confidence: 88%

“…[54] In another Egyptian study, IL-12 serum concentrations were significantly higher in patients with liver cirrhosis when compared to healthy individuals (P < .001). [55] In all our HCV/RNA positive patients, serum IL-12 levels decreased significantly after initiating treatment, in both dualand triple-therapy groups. Similarly, Xu et al reported a decrease of IL-12 after treatment with SOF--RBV.…”

Section: Discussionmentioning

confidence: 67%

“…[ 54 ] In another Egyptian study, IL-12 serum concentrations were significantly higher in patients with liver cirrhosis when compared to healthy individuals ( P < .001). [ 55 ]…”

Section: Discussionmentioning

confidence: 99%

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Prediction of response to sofosbuvir-based therapy using serum interleukin-12 and single nucleotide polymorphism of the interleukin 28B gene as predictive factors in HCV positive genotype-4 patients

Mohamed Abdelnajid,

Elmowafy,

Rostaing

et al. 2023

Medicine

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Some hepatitis-C virus patients have resistance to direct-acting-antivirals (DAAs). Genetic polymorphisms have been associated with drug resistance. This study aimed to evaluate the role of interleukin (IL)-28B gene polymorphism and IL-12 levels as predictors for a response to sofosbuvir/ribavirin (SOF/RBV) with (triple-therapy) or without (dual-therapy) Peg-alpha-interferon. 92 hepatitis C virus (HCV)/RNA (+)-patients treated with dual (n = 72) or triple (n = 20) therapy. IL28B genetic polymorphism and IL-12 level assessments. 30.4% of the patients were IL28B C/C genotype, 56.5% C/T-genotype, and 13% T/T-genotype. Mean baseline IL-12 levels were 27.5 ± 3.0 pg/mL. Rapid viral response was achieved in 86/92 patients. All patients achieved end-of-treatment virologic response. The 12- and 24-week sustained virologic responses (SVR) were achieved in 76 patients (82.6%), that is, a relapse was found in 16 patients (17.4%). 8 and 12-weeks after antiviral therapy, IL-12 levels decreased significantly, and became comparable to those of the control-group. That drop in IL-12 levels was similar across the dual- and triple-therapy patients. Finally, logistic regression analysis showed that the increase in baseline aspartate aminotransferase (AST) and T/T genotyping had an independent effect on increasing the probability a SVR failing in both dual- and triple-therapy groups (P = .0007 and P = .02, respectively). Single-nucleotide polymorphism (SNP) in IL-28B and IL-12 levels play roles as predictors in DAAs resistance.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 67%

“…[ 54 ] In another Egyptian study, IL-12 serum concentrations were significantly higher in patients with liver cirrhosis when compared to healthy individuals ( P < .001). [ 55 ]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations