Study of Ki67 and CD10 expression as predictive factors of recurrence of ameloblastoma

Ahlem, Bdioui; Wided, A.; Amani, L; Nadia, Z; Amira, Arfaoui Toumi; Faten, Fdhila

doi:10.1016/j.anorl.2015.08.016

Cited by 24 publications

(19 citation statements)

References 18 publications

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“…Immunohistochemical analysis of Ki-67 labelling has a brownish staining of nuclear areas as well as focal and total nuclear positivity of tumor cells [ 10 ] similar to our IHC findings of Ki-67 on an incisional biopsy specimen.…”

Section: Discussionsupporting

confidence: 78%

Acanthomatous Ameloblastoma of Mandible in a Paediatric Patient

Narasimhan

Giri

Pandyan

et al. 2018

Case Reports in Pediatrics

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Ameloblastoma is a slow-growing, benign odontogenic tumor derived from odontogenic epithelial components with a mature fibrous stroma. It is the second most common odontogenic neoplasm following odontome. Acanthomatous ameloblastoma histologically presents with squamous epithelial metaplastic transformation of odontogenic tissue. The present case report of a 12-year-old male exclusively elaborates the issues concerned with the aggressive nature of acanthomatous ameloblastoma (AA) which is a distinctive variant of ameloblastoma.

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Section: Discussionsupporting

confidence: 78%

Acanthomatous Ameloblastoma of Mandible in a Paediatric Patient

Narasimhan

Giri

Pandyan

et al. 2018

Case Reports in Pediatrics

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“…Solid/multicystic variant is the most common type, and it is highly aggressive and has a 90% recurrence after conservative management such as curettage and enucleation [ 5 ]. The high rate of recurrence is observed in mandibular ameloblastomas than maxillary ameloblastomas [ 6 ] and in follicular type than in plexiform or any other type [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The genetic theory explains the involvement of the BRAF protein in the mitogen-activated protein kinase pathway (MAPK) that has been commonly found to be mutated, rendering the pathway constitutively active [ 7 ]. Ahlem et al observed that the cell proliferation activity evaluated by Ki67 and CD10 was significantly higher in recurrent tumours [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Ameloblastoma: A Surgical Challenge

Aramanadka

Kamath

Kudva

2018

Case Reports in Dentistry

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Ameloblastoma is locally aggressive benign odontogenic tumour with increased risk of recurrence rate. The choice of treatment depends on the histologic subtype. Radical therapy is the recommended modality for solid ameloblastomas. The possibilities of recurrence even after enbloc resection are still high. The author presents two case reports of recurrent ameloblastomas postradical resection. First case describes the recurrence of ameloblastoma in the bone graft which was used for reconstruction, and the second case depicts recurrence in the infratemporal fossa. Intraoperative radiography of the frozen section of the soft tissue margin plays an important role in the holistic management of these lesions.

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“…In the current reported cases, however, these investigations could not be carried out due to reasons such as unavailability of reagents for carrying such investigations and the cost of acquiring these reagents. Immunohistochemistry for Ki 67 was done, however, it does not speci cally point out to metastatic ameloblastoma but rather indicates local invasiveness and recurrences of ameloblastoma, thereby its prognosis [20,21].…”

Section: Declarationsmentioning

confidence: 99%

A rare case of maxillary ameloblastoma with lung metastasis: a case report

Sohal

Mlaga

Vuhahula

2020

Preprint

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Background Ameloblastomas are low-grade neoplasms of odontogenic epithelium that account for about 1% of all oral tumours and about 10% of odontogenic tumours. Rarely, these tumours have a potential of distance metastasis, and once they do metastasize, they are termed as metastatic ameloblastoma. Case presentation A 24-year-old African man presented with a massive swelling on the right side of the face for 2 years in 2018. He was previously operated for a swelling in the right side of the maxilla in 2012, which was histologically diagnosed as ameloblastoma. Clinical and radiological evaluation revealed a massive maxillary tumour that had a local extension to the brain. X-ray and CT scan of chest pointed out to metastatic mass in the lungs. Histology of the recurrent tumour mass revealed it to be follicular ameloblastoma and CT-guided fine-needle aspiration cytology of the lung mass showed microscopic features of ameloblastoma similar to primary jaw tumour. Conclusion A Close and long-term follow-up is mandatory in patients diagnosed with ameloblastoma even years after primary resection.

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Study of Ki67 and CD10 expression as predictive factors of recurrence of ameloblastoma

Abstract: The Ki67 proliferation index and stromal CD10 expression can be considered to be predictive factors of ameloblastoma recurrence.

Cited by 24 publications

References 18 publications

Acanthomatous Ameloblastoma of Mandible in a Paediatric Patient

Acanthomatous Ameloblastoma of Mandible in a Paediatric Patient

Recurrent Ameloblastoma: A Surgical Challenge

A rare case of maxillary ameloblastoma with lung metastasis: a case report

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