Purpose of this paper is to improve parameters of metal structures elements of hoisting-and-transport machines (HTMs) by means of systematic approach to study changes of their stress-strain state during design or usage stage. Subject of the study is pattern of changes in distribution and values of stresses in elements of metal structures of HTMs depending on the structural and parametric characteristics. Design methodology of metal structures of HTMs on the basis of a portal crane is proposed, it is based on strength calculations using methods of allowable stresses and FEM, 3D computer simulation, system analysis of the stress-strain state and structural-parametric synthesis. Results of modeling of loading state and calculations of the portal crane metal structures on strength by FEM in CAD/CAE system, analysis of their stress-strain state, structural-parametric synthesis are presented. Recommendations on practical application of the results are given. Possible ways of further development of proposed solutions are identified.