Study of light propagation in human, rabbit and rat liver tissue by Monte Carlo simulation

Kumari, Sulekha; Nirala, Anil Kumar

doi:10.1016/j.ijleo.2010.06.006

Cited by 13 publications

(9 citation statements)

References 17 publications

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“…Generally, all MC model variants follow the same principles but can be applied to tissues modelled as two‐layer models , seven layers and nine layers , among others. MC methods have been used to quantify the interactions between light and blood , skin lesions , breast tumours , liver tissue and for retinal oximetry . MC methods have been improved by using scaling and perturbation for the detection of tumour‐like heterogeneities and parallel computation has been used to improve the speed and efficiency of the algorithm .…”

Section: Related Workmentioning

confidence: 99%

Optical investigation of three‐dimensional human skin equivalents: A pilot study

Kallepalli

McCall

James

et al. 2019

Journal of Biophotonics

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Human skin equivalents (HSEs) are three‐dimensional living models of human skin that are prepared in vitro by seeding cells onto an appropriate scaffold. They recreate the structure and biological behaviour of real skin, allowing the investigation of processes such as keratinocyte differentiation and interactions between the dermal and epidermal layers. However, for wider applications, their optical and mechanical properties should also replicate those of real skin. We therefore conducted a pilot study to investigate the optical properties of HSEs. We compared Monte Carlo simulations of (a) real human skin and (b) two‐layer optical models of HSEs with (c) experimental measurements of transmittance through HSE samples. The skin layers were described using a hybrid collection of optical attenuation coefficients. A linear relationship was observed between the simulations and experiments. For samples thinner than 0.5 mm, an exponential increase in detected power was observed due to fewer instances of absorption and scattering.

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Section: Related Workmentioning

confidence: 99%

Optical investigation of three‐dimensional human skin equivalents: A pilot study

Kallepalli

McCall

James

et al. 2019

Journal of Biophotonics

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“…In order to properly select wavelengths and source to detector separations, optical modeling of the tissue of interest was performed using the Monte Carlo method. This method has been used to estimate light fluence through different types of tissue [20,21]. A commonly used software simulation program developed by Wang et al [22], multi-layer Monte Carlo(MCML), estimates tissue as homogenous rectangular domains.…”

Section: Introductionmentioning

confidence: 99%

In-silico and in-vitro investigation of a photonic monitor for intestinal perfusion and oxygenation

Robinson

Butcher

Wilson

et al. 2017

Biomed. Opt. Express

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Abstract:The quantification of visceral organ oxygenation after trauma-related systemic hypovolemia and shock is critical to enable effective resuscitation. In this work, a photoplethysmography-based (PPG) sensor was specifically designed for probing the perfusion and oxygenation condition of intestinal tissue with the ultimate goal to monitor patients post trauma to guide resuscitation. Through Monte Carlo modeling, suitable optofluidic phantoms were determined, the wavelength and separation distance for the sensor was optimized, and sensor performance for the quantification of tissue perfusion and oxygenation was tested on the in-vitro phantom. In particular, the Monte Carlo simulated both a standard block three-layer model and a more realistic model including villi. Measurements were collected on the designed three layer optofluidic phantom and the results taken with the small form factor PPG device showed a marked improvement when using shorter visible wavelengths over the more conventional longer visible wavelengths. Overall, in this work a Monte Carlo model was developed, an optofluidic phantom was built, and a small form factor PPG sensor was developed and characterized using the phantom for perfusion and oxygenation over the visible wavelength range. The results show promise that this small form factor PPG sensor could be used as a future guide to shock-related resuscitation.

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“…It is felt that this technique holds great potential for tissue characterization in general and for early detection of cancers of soft tissues in particular [3][4][5][6][7][8][9][10]. In a precancerous soft tissue the size of cell nuclei increases.…”

Section: Introductionmentioning

confidence: 99%

On the validity of the anomalous diffraction approximation in light-scattering studies of soft biomedical tissues

Sharma

Banerjee

2012

Journal of Modern Optics

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In simulations of light propagation in soft biomedical tissues, the tissue is generally modeled as a turbid medium. In one such model, suspended scatterers are assumed to be homogeneous spheres of size following a fractal size distribution law. In this paper, we examine, within the framework of this model, the accuracy of a well-known approximation known as the anomalous diffraction approximation. The deployment of this approximation allows the tissue scattering coefficient to be expressed in a closed analytic form. It is demonstrated that use of the anomalous diffraction approximation yields reasonably good results for the tissue scattering coefficient, the phase function and the asymmetry parameter. It is also shown that the experimentally observed wavelength dependence of the scattering coefficient follows analytically from the formulas obtained using this approximation. The results are important from the point of view of constructing more realistic tissue models which may include non-spherical scatterers.

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Study of light propagation in human, rabbit and rat liver tissue by Monte Carlo simulation

Cited by 13 publications

References 17 publications

Optical investigation of three‐dimensional human skin equivalents: A pilot study

Optical investigation of three‐dimensional human skin equivalents: A pilot study

In-silico and in-vitro investigation of a photonic monitor for intestinal perfusion and oxygenation

On the validity of the anomalous diffraction approximation in light-scattering studies of soft biomedical tissues

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