Study of Lipid Profile in Patients With Subclinical Hypothyroidism

Abstract

A prospective case control study of lipid profile abnormalities in patients with subclinical hypothyroidism in J. L. N Hospital Ajmer. METHODS: 25 cases and 25 controls were included into the study. Cases had TSH> 5.0µIU/ml with normal T3 and T4 values. Controls were euthyroid patients. A detailed history, clinical examination, investigations like complete blood counts, fasting blood sugars, fasting thyroid profile and fasting lipid profile were done for all cases and controls. RESULTS: The mean TSH level in subclinical hypothyroidism cases (n=25) was 10.01±3.87miIU/L, when compared to euthyroid controls (n=25), it was 2.69±1.52 miIU/L. The mean LDL cholesterol level in subclinical hypothyroidism cases (n=25) was 93.9±16.6mg/dl, when compared to controls, it was 84.7±11.6mg/dl. CONCLUSION: The present study showed a higher prevalence of subclinical hypothyroidism among females of reproductive age group. significantly higher levels of total cholesterol, Triglyceride and VLDL cholesterol in patient with subclinical hypothyroidism, though elevation in LDL cholesterol level was found to be statistically significant, but it remained well within the upper limit of normal, hence it is clinically significant and there was no statistically significant relation found between HDL cholesterol and subclinical hypothyroidism.