Study of lipid profile parameters abnormalities in patients with sickle cell disease from single centre study in central India

Gupta, Manoj; Sharma, Pinki; Vishwakarma, Sumit Kumar; Bhalke, Lokesh; Chandra, Umesh Kumar

doi:10.18203/2349-3933.ijam20202103

Cited by 2 publications

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“…[3,13] The lipid profile in sickle cell anaemia is typified by low levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) but increased levels of triglycerides (TG)levels. [1,3,11,14] Dyslipidaemia is a risk factor for coronary artery disease and pulmonary hypertension in sickle cell disease and requires more evaluation. [2] Literature on the status of plasma lipids in patients with SCD needs to be improved in southeast Nigeria, while global data are conflicting.…”

Section: 2023______________________248mentioning

confidence: 99%

Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria

Nnachi,

Edenya,

Okoye

et al. 2023

Ann Health Res

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Background: Dyslipidaemia has been implicated in the pathophysiology of sickle cell disease (SCD) complications; hence its role requires further elucidation. Objectives: To investigate the relationship between disease severity and plasma lipid levels of patients with sickle cell anaemia. Methods: A cross-sectional study design was used for the survey. A total of 50 patients with sickle cell anaemia and 50 controls without SCD were recruited for the study. The clinical data and plasma lipid levels of lipids and haemoglobin parameters were analysed. Results: The majority of the participants were aged 18-25 years. Total plasma cholesterol and HDL-C were significantly lower in individuals with SCA compared with the controls (3.3±1.2 vs 4.2±1.2; p<0.001) and (1.3±0.5 vs 1.5±0.4; p = 0.038) respectively. Most patients with SCA had moderate disease severity (24; 48%). There was no statistically significant difference in the plasma levels of total cholesterol and HDL-C across the disease severity groups of SCA (p = 0.694 and 0.262). There was also no significant correlation between total cholesterol, HDL-C, and markers of haemolysis, haemoglobin F, and haemoglobin S levels. Conclusion: SCA is characterised by lower mean plasma TC and HDL than controls. However, no relationship was found between TC, HDL levels and SCD disease severity, markers of haemolysis, HbF and HbS levels. Further studies are required to ascertain the implications of plasma lipid levels in SCD.

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Section: 2023______________________248mentioning

confidence: 99%

Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria

Nnachi,

Edenya,

Okoye

et al. 2023

Ann Health Res

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Prevalence of metabolic syndrome in sickle cell disease patients: A cross‐sectional study at a tertiary hospital in Nepal

Khadayat,

Bishwakarma,

Pant

et al. 2024

eJHaem

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BackgroundSickle cell disease (SCD) is the most common hemoglobinopathy caused by an autosomal recessive genetic disorder leading to increased morbidity and mortality rates. SCD is prevalent in the Tharu community in the lowland (Terai) region of Nepal. Prevalence of metabolic syndrome among adults with SCD is poorly studied.MethodologyThis prospective cross‐sectional study was conducted at Seti Provincial Hospital in Dhangadhi, Nepal, among 140 adolescents and adults with SCD, aged 15–60 years. Anthropometric and laboratory data were collected using an assisted questionnaire, and the SPSS software version 23 was used for data analysis. Descriptive and inferential statistics were used to summarize the presence of metabolic syndrome and were stratified in separate analyses by age and sex. National Cholesterol Education Program‐Adult Treatment Panel III criteria were used to define metabolic syndrome.AimThis cross‐sectional study aimed to assess the prevalence of metabolic syndrome among SCD patients with SCD registered at the Seti Provincial Hospital in Dhangadhi, Nepal.ResultsThe prevalence of metabolic syndrome in the study participants was 7.8%. Our study revealed 5% of the patients overweight, and 1.4% obese. In this study, the mean triglyceride level was 118.5 mg/dL, and the mean high‐density lipoprotein (HDL) level was 36.2 mg/dL (men) and 36.7 mg/dL (women). This study found that the mean fasting blood glucose level was 88.6 gm/dL. Similarly, 3.5% of patients had increased systolic blood pressure, and 7.8% had raised diastolic blood pressure. Study shows that changes in triglyceride level (p = 0.013), waist circumference, and HDL level (p = 0.0001 and 0.0048, respectively) are significantly associated with smoking or alcohol consumption; however, change in blood pressure (p = 0.013) and fasting blood sugar level (p = 0.086) are not associated with smoking or alcohol consumption.ConclusionStudy concluded that though a lower proportion of SCD patients met the criteria for metabolic syndrome than in studies conducted in developed countries, it is crucial to consider metabolic syndrome while managing patients with SCD. Nevertheless, the authors advocate a more comprehensive study to draw significant conclusions.

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Study of lipid profile parameters abnormalities in patients with sickle cell disease from single centre study in central India

Cited by 2 publications

References 0 publications

Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria

Plasma Lipid Levels in Relation to Disease Severity in Sickle Cell Anaemia in Abakaliki, Southeast Nigeria

Prevalence of metabolic syndrome in sickle cell disease patients: A cross‐sectional study at a tertiary hospital in Nepal

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