Study of Lyme borreliosis in Ukraine

Biletska, Halyna; Podavalenko, Larysa; Semenyshyn, Oksana; Lozynskyj, Ihor; Tarasyuk, Oleksandra

doi:10.1016/j.ijmm.2008.04.004

Cited by 13 publications

(15 citation statements)

References 11 publications

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“…As predicted, if Borrelia-mediated selection affects the largescale geographical distribution of the protective TLR2 variant, there was a positive association between the frequency of TLR2 c 2 in bank vole populations and human LB incidence across 19 [17,[20][21][22]. Rather, the strong association between human LB incidence and the frequency of the protective TLR2 c 2 variant in bank vole populations indicates that Borrelia-mediated selection has shaped the evolution of this innate immune receptor in wild rodents.…”

Section: Resultsmentioning

confidence: 61%

Borrelia burgdorferi sensu lato infection pressure shapes innate immune gene evolution in natural rodent populations across Europe

Tschirren

2015

Biol. Lett.

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Although parasite-mediated selection is assumed to be the main driver of immune gene evolution, empirical evidence that parasites induce allele frequency changes at host immune genes in time and/or space remains scarce. Here, I show that the frequency of a protective gene variant of the innate immune receptor Toll-like receptor 2 in natural bank vole (Myodes glareolus) populations is positively associated with the strength of Borrelia burgdorferi sensu lato infection risk across the European continent. Thereby, this study provides rare evidence for the role of spatially variable infection pressures in moulding the vertebrate immune system.

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Section: Resultsmentioning

confidence: 61%

Borrelia burgdorferi sensu lato infection pressure shapes innate immune gene evolution in natural rodent populations across Europe

Tschirren

2015

Biol. Lett.

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“…We found moderate seroprevalence (2.4%) for B. burgdorferi compared with findings for other countries in the region. For instance, a serosurvey in Ukraine found seroprevalences of 25%–38% in a healthy population depending on the ecologic zone ( 43 ). However, seroprevalence could be caused by other Borrelia species in that region and might not be specific to the Lyme disease group of Borreliae .…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for and Seroprevalence of Tickborne Zoonotic Diseases among Livestock Owners, Kazakhstan

Head¹,

Bumburidi²,

Mirzabekova³

et al. 2020

Emerg. Infect. Dis.

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Crimean-Congo hemorrhagic fever (CCHF), Q fever, and Lyme disease are endemic to southern Kazakhstan, but population-based serosurveys are lacking. We assessed risk factors and seroprevalence of these zoonoses and conducted surveys for CCHF-related knowledge, attitudes, and practices in the Zhambyl region of Kazakhstan. Weighted seroprevalence for CCHF among all participants was 1.2%, increasing to 3.4% in villages with a known history of CCHF circulation. Weighted seroprevalence was 2.4% for Lyme disease and 1.3% for Q fever. We found evidence of CCHF virus circulation in areas not known to harbor the virus. We noted that activities that put persons at high risk for zoonotic or tickborne disease also were risk factors for seropositivity. However, recognition of the role of livestock in disease transmission and use of personal protective equipment when performing high-risk activities were low among participants.

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“…Previous studies in Ukraine (Movila et al 2009) have provided insight into tick-borne encephalitis (TBE), a disease caused by a Flavivirus, and Lyme disease (LD), caused by the spirochete, Borrelia burgdorferi (Biletska et al 2008). From 2004 to 2014, the highest rate of registered cases of LD was 4.1 per 100,000 people in Ukraine (Biletska et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Prevalence ofAnaplasma phagocytophiluminIxodes ricinusandDermacentor reticulatusand Coinfection withBorrelia burgdorferiand Tick-Borne Encephalitis Virus in Western Ukraine

Ben

Lozynskyi

2019

Vector-Borne and Zoonotic Diseases

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Introduction: Tick-borne encephalitis virus (TBEV) and Borrelia burgdorferi, the causative agent of Lyme disease (LD), are widespread in Western Ukraine. However, relatively little is known about Anaplasma phagocytophilum in this region. This study examined patterns of infection with A. phagocytophilum in two tick vectors compared with the better studied TBEV and B. burgdorferi.Materials: Ticks were collected in three different ecosystems of the Western Ukraine during 2009–2014. Samples were examined for pathogen detection using real-time polymerase chain reaction (PCR), and logistic regression models were developed to assess the significance of different factors.Results: Among the three selected ecological systems of the Western region of Ukraine, 5130 ticks belonging to Ixodes ricinus and Dermacentor reticulatus were collected between 2009 and 2014. They were grouped into 366 pools and were tested by PCR for A. phagocytophilum. A subsample (1620 ticks, 162 pools) of the ticks was concurrently tested by PCR for A. phagocytophilum, B. burgdorferi, and TBEV. Overall, there was no trend in the proportion of positive ticks across years (p > 0.05). However, the prevalence of A. phagocytophilum was higher (27.4%) in I. ricinus than in D. reticulatus (15.9%) (OR = 2.69; 95% CI, 1.52–4.94 (Lower, Upper 95% CI)). Infection was more common in forested habitats (OR = 1.89; 95% CI, 1.07–3.36) and during the later summer–early autumn (3.78; 95% CI, 1.79–8.06). B. burgdorferi was found in 29.3% and 31.9% of I. ricinus and D. reticulatus, respectively; and TBEV was found in 6.3% and 14.5% of I. ricinus and D. reticulatus. Coinfection of A. phagocytophilum and B. burgdorferi occurred more often than chance and was more frequent than any other combination of pathogens (p = 0.031).Conclusions: Our study is the first to explore the potential relationship between the ecosystems, vectors, and the presence of Human Granulocytic Anaplasmosis (HGA) and other tick-borne infections in Western Ukraine. Anaplasma demonstrated a greater prevalence in I. ricinus in the forested area in Western Ukraine. Altogether, HGA, LD, and tick-borne encephalitis (TBE) pathogens are actively circulating in these ecosystems and have the potential to coinfect vectors that might increase the risk of transmitting multiple pathogens to humans during host feeding by individual ticks.

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Study of Lyme borreliosis in Ukraine

Cited by 13 publications

References 11 publications

Borrelia burgdorferi sensu lato infection pressure shapes innate immune gene evolution in natural rodent populations across Europe

Borrelia burgdorferi sensu lato infection pressure shapes innate immune gene evolution in natural rodent populations across Europe

Risk Factors for and Seroprevalence of Tickborne Zoonotic Diseases among Livestock Owners, Kazakhstan

Prevalence ofAnaplasma phagocytophiluminIxodes ricinusandDermacentor reticulatusand Coinfection withBorrelia burgdorferiand Tick-Borne Encephalitis Virus in Western Ukraine

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