Study of mast cells in prostate lesions: Adenocarcinoma compared with hyperplasia

Vittal, Rakshith; Kumar, M L Harendra

doi:10.4103/2278-0513.176252

Cited by 3 publications

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“…In contrast to our study Stawerski et al, 16 Nonomura et al 17 and Rakshith V et al 7 drew inference of increased number of mast cells in patients of prostate cancer than in benign conditions suggesting a stimulating role of mast cells in progression of cancer.…”

Section: Discussioncontrasting

confidence: 99%

“…Mast cells are pervasive and distributed throughout body especially in connective tissue, vessels and nerves that are closest to external surface. 7 Mast cells known for their role in allergy and anaphylaxis now currently act as versatile, resourceful element in immune mediated angiogenesis, tissue repair, tissue remodeling and homeostasis. 8 Mast cells in some tumors act as protumori genic and influence the advancement of cancer cells by stimulating neovascularity.…”

Section: Introductionmentioning

confidence: 99%

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Consortum between mast cell and prostatic lesions-An etiological factor or mere coexistence

Vani¹,

A²,

Bharathi³

2020

IJPO

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Prostate cancer exhibits a complex genetic and heterogeneous histological pattern reflecting its multifactorial phenotype. Mast cells mainly known for their role in allergy and anaphylaxis, now regarded as key factor cell in angiogenesis, tissue remodeling and repair, whereas their importance in tumor pathology as either cancer promoter or inhibitor is still debated. Materials and Methods: Study included 100 cases of prostatic lesions with 74 cases of benign prostatic lesions and 26 cases of adenocarcinoma prostate, received in the form of transurethral resection of prostate chips for histopathological examination. The tissues were routinely processed, the paraffin sections stained by hematoxylin and eosin and 1% toluidine blue. Histological diagnosis was made. Mast cell count was done taking a standard of 10 high power fields(x40) and mean were calculated. Distributions of mast cells were noted in stroma, perivascular, periglandular and intraglandular regions. Results: Mast cell count was significantly higher in benign prostatic hyperplasia with mean of 3.6 per high power field whereas absence or low count was found in adenocarcinoma prostate with mean of 1.7 per high power field. Mast cells were located predominantly in stromal region in both BPH and adenocarcinoma prostate; in rest of the areas the numbers were comparable. Conclusion: In this study we observed significant increase in mast cell count in stroma of BPH compared to adenocarcinoma indicating that mast cell density is inversely proportional to malignancy. This suggests high mast cell count favors the prognosis.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Consortum between mast cell and prostatic lesions-An etiological factor or mere coexistence

Vani¹,

A²,

Bharathi³

2020

IJPO

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“…The authors observed a significant increase in the number of mast cells in patients with adenocarcinoma as compared to benign prostatic hyperplasia and postulated a stimulating role of mast cells in the progression of cancer. [13] Aydin et al (2002) investigated the utility of mast cells in evaluating benign and malignant prostate lesion. Mast cells were more frequently observed in the fibromuscular area than in the adenomatous area in BPH cases.…”

Section: Discussionmentioning

confidence: 99%

Mast Cell Profile in Benign and Malignant Prostatic Lesions

Das

Sumanth

2018

APALM

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Introduction: Mast cells have an important role in innate and adaptive immunity. There role in tumour pathology is under investigation due to studies linking them to angiogenesis, tissue remodeling and stromal immunomodulation. Reports suggest that they can exert both pro or anti tumour effects. The role of mast cells may be influenced by its location in the lesion. In the present study, the number and distribution of mast cells in both benign and malignant prostatic lesions were recorded. Methodology: Fifty seven patients of benign prostatic hyperplasia (BPH) and 43 patients of adenocarcinoma (Ca) were the subjects of the study. Inflammatory conditions of prostate like prostatitis and other malignancies of prostate like sarcoma, transitional cell carcinoma etc were excluded from the study. This was a descriptive study with purposive sampling. Histological diagnosis was made by examining sections stained with Haematoxylin and Eosin. Additional sections from the same block were stained for mast cells using Giemsa stains as per standard protocol. Mast cell count was done in minimum 6 random high power microscopy field in four different regions viz., intraglandular, periglandular, stromal and perivascular regions for BPH and intratumoral, peritumoral, stromal and perivascular regions for Ca. Results were analysed statistically. Results: BPH cases showed significantly higher number of mast cells in stromal as well as periglandular areas followed by perivascular area. Only few mast cells were observed in intraglandular area. Similar was the observations in adenocarcinoma cases where the maximum number of mast cells were concentrated in the stromal and perilesional area. The number of mast cells in stroma of BPH was higher as compared to that of adenocarcinoma. In rest of the areas, the numbers were comparable. Conclusion: This study showed no remarkable difference in the number and distribution of mast cells in benign and malignant prostatic lesions. There is paucity of such studies in the literature and the possible utility of mast cell count to differentiate malignant from benign and atypical conditions needs further evaluation.

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Significance of Mast Cells in Benign and Malignant Conditions of Prostate

Kumar

Potekar

Arakeri

2021

PIJR

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Introduction: Mast cells are the one of the component of defense immunity of our body.Aims of the study:Role of mast cell in benign and malignant condition of prostate.Materials & methods:Total number of cases is 32.Out of 32 cases,24 cases are Benign (BPH) and 8 cases are malignant. Special stain ie.Toluidine blue has been done in all the 32 cases, as toluidine blue stain will highlight the mast cells accurately.The number of mast cells per 10 high power fields in both benign and malignant conditions was compared using statistical tools.Results: Proportion of mast cell in benign lesions is 0.58 while in malignancy is 0.63.Since the p-value was > 0.05,the results were considered as statistically insignificant. Discussion: In the present study, it is found that there is no statistical significant increase in the number of mast cells. Conclusion: Hence probably mast cells may not play any protumorogenic role in cases of prostatic malignancy.

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Study of mast cells in prostate lesions: Adenocarcinoma compared with hyperplasia

Cited by 3 publications

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Consortum between mast cell and prostatic lesions-An etiological factor or mere coexistence

Consortum between mast cell and prostatic lesions-An etiological factor or mere coexistence

Mast Cell Profile in Benign and Malignant Prostatic Lesions

Significance of Mast Cells in Benign and Malignant Conditions of Prostate

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