Study of Maternal Risk Factors Contributing in the Development of Congenital Hypothyroidism

Shorbagy, Eman Abdalla El; Salem, Ihab Mohamed A.; Zaki, Seham Mahrous; Din, Islam Maher Wahid El

doi:10.21608/zumj.2018.13230

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Egypt is one of the countries with low iodinated salt intake and a substantial number of neonates suffering from iodine insufficiency, according to UNICEF [3].…”

Section: Congenital Hypothyroidismmentioning

confidence: 99%

See 1 more Smart Citation

Newborn Screening for Congenital Hypothyroidism and Congenital Adrenal Hyperplasia in Egypt

ElBakry

2022

Annals of Neonatology Journal

View full text Add to dashboard Cite

Newborn screening (NBS) is considered one of the most successful public health programs in the Egypt.It helps identification conditions in asymptomatic newborns at birth, which are known to cause severe morbidity and mortality, with timely treatment prior to disease presentation, thus preventing poor longterm outcomes. Two disorders, congenital adrenal hyperplasia (CAH) and congenital hypothyroidism (CH), when untreated, can lead to devastating, irreversible and fatal outcomes. Permanent cognitive impairment, growth failure and dysmorphic features are seen in congenital hypothyroidism (CH) and early infant death in males with salt loosing CAH (as most females are discovered by presence of atypical genitalia, while males appeared normal). Newborn screening (NBS) for congenital hypothyroidism (CH) was more rapidly adopted throughout Egypt, while NBS for congenital adrenal hyperplasia (CAH) was recently added. Early treatment of CAH is much simpler with taking a pill a day unlike CAH requiring multiple medication doses, and possibly surgery apart from enteral and parenteral stress doses during adrenal crisis. Early newborn screening specifically for those two disorders has a great importance for early diagnosis, early intervention and prevention of catastrophic outcomes.

show abstract

“…Egypt is one of the countries with low iodinated salt intake and a substantial number of neonates suffering from iodine insufficiency, according to UNICEF [3].…”

Section: Congenital Hypothyroidismmentioning

confidence: 99%

“…Although most females were thought to be discovered by the presence of what is now called atypical genital appearance, NBS has identified cases in females, when clinically not suspected [3].…”

Section: Introductionmentioning

confidence: 99%

Newborn Screening for Congenital Hypothyroidism and Congenital Adrenal Hyperplasia in Egypt

ElBakry

2022

Annals of Neonatology Journal

View full text Add to dashboard Cite

show abstract

“…The Egyptian Ministry of Health and Population (MOHP) has approved the use of the TSH assay method to screen for congenital hypothyroidism (CH) [4]. to be significant, and these autoimmune antibodies, in turn, increase the rates of maternal miscarriage, neonatal prematurity, and low birth weight [5].…”

Section: Thyroidmentioning

confidence: 99%

Screening for Thyroid Dysfunction among Preterm Infants at Manfalout General Hospital, Assiut, Egypt

Mohamed

El-Masry

Hassan

et al. 2021

Annals of Neonatology Journal

View full text Add to dashboard Cite

Background: Neonatal hypothyroidism is a serious endocrinal disorder that must be diagnosed promptly to avoid irreversible neurological deficits. Aim of work: screening of all preterm infants for thyroid dysfunction. Patients and methods: All preterm infants enrolled to this study were subjected to thorough history taking and complete physical examinations. Investigations: initially screening for hypothyroidism was done according to Egyptian screening program and serum TSH, T4, and free T4 were done within the 1st week of life and repeated at the end of 2nd and 4th week of life for those with abnormal results only. Results: Abnormal thyroid function was detected in 178 (50%) preterm infants.Twenty-two infants were excluded from the study. Mean serum levels of TSH, T4 and free T4 were higher among group II infants (more mature) than 1st group (less mature). The mean levels of T4 and free T4 were higher at the end of 4th week of life than their levels during the 1st week of life. Transient hypothyroxinemia was more frequent thyroid dysfunction disorders among both groups (52.5 % and 38 % for 1st and 2nd groups respectively). Neonatal hypothyroidism, transient primary neonatal hypothyroidism, and transient hyperthyrotropinemia were detected in 9 (11.25%), 18 (22.5%), and 11 neonates (13.75%), respectively for the 1st group and observed in 7 (9.2%), 14 (18.4%), and 9 neonates (11.8%), respectively for the second group Conclusions: Thyroid dysfunction was moderately common among preterm neonates. Protocol for thyroid function tests among preterm infants is essential.

show abstract

Study of Maternal Risk Factors Contributing in the Development of Congenital Hypothyroidism

Cited by 2 publications

References 0 publications

Newborn Screening for Congenital Hypothyroidism and Congenital Adrenal Hyperplasia in Egypt

Newborn Screening for Congenital Hypothyroidism and Congenital Adrenal Hyperplasia in Egypt

Screening for Thyroid Dysfunction among Preterm Infants at Manfalout General Hospital, Assiut, Egypt

Contact Info

Product

Resources

About