Study of Micellar Behavior of SDS and CTAB in Aqueous Media Containing Furosemide—A Cardiovascular Drug

Chauhan, Suvarcha; Chauhan, M. S.; Kaushal, Deepika; Syal, V. K.; Jyoti, J.

doi:10.1007/s10953-010-9534-9

Cited by 64 publications

(32 citation statements)

References 15 publications

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“…CTAC of purity >99 % was obtained from Acros Organics, dried under vacuum and used as received. Cationic dimeric surfactant, di(dodecyldimethyl ammonium bromide) (12,2,12) was synthesized from N,N,N,N-tetramethylenediamine (TEMED) {AR graded} with n-dodecylbromide as given in the literature [9]. The purity of the sample was checked by estimating the CMC value of the surfactant in water (0.96 × 10 −3 ) which agreed well with the literature value [9].…”

Section: Methodsmentioning

confidence: 68%

Sound Speed and Density Studies of Interactions Between Cationic Surfactants and Aqueous Gelatin Solution

Chauhan

et al. 2012

Int J Thermophys

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Studies on the interactions of surfactants with proteins can contribute to an understanding of the action of surfactants as denaturants and as solubilizing agents for membranes of proteins and lipids. Quantitative aspects of such studies may include direct measurements of properties, such as viscosity, density, sound speed, conductance, and elucidation of the often highly complex phase diagrams. In this study, sound speed and density studies of surfactants, viz., cetyltrimethyl ammonium bromide, cetyltrimethyl ammonium chloride, and di(dodecydimethyl ammonium bromide) (12-2-12) have been carried out in a 0.02 % w/v aqueous solution of gelatin at temperatures of 20 • C, 25 • C, 30 • C, and 35 • C. From the measured data, the parameters apparent molar volumes (φ v ), adiabatic compressibility (β), and apparent molar compressibility (φ k ) have been calculated to interpret the protein-surfactant interactions. The variations in these parameters with the concentration of the surfactant suggests the manifestation of hydrophobic interactions in the system.

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Section: Methodsmentioning

confidence: 68%

Sound Speed and Density Studies of Interactions Between Cationic Surfactants and Aqueous Gelatin Solution

Chauhan

et al. 2012

Int J Thermophys

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“…Our density data of sodium dodecyl sulphate in presence of cetyltrimethylammonium bromide in pure water and in methanol–water mixtures are found to be higher than the density data of sodium dodecyl sulphate in pure water and in methanol–water mixtures (Bhattarai et al 2011). It is because the presence of cetyltrimethylammounium bromide with sodium dodecyl sulphate will naturally increase the density and decrease with increasing temperature (Chauhan et al 2010). Obviously, the concentration dependence of density follows one and the same pattern at all the temperatures and solvent composition investigated.…”

Section: Resultsmentioning

confidence: 99%

Effects of concentration, temperature and solvent composition on density and apparent molar volume of the binary mixtures of cationic-anionic surfactants in methanol–water mixed solvent media

2013

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The accurate measurements on density of the binary mixtures of cetyltrimethylammonium bromide and sodium dodecyl sulphate in pure water and in methanol(1) + water (2) mixed solvent media containing (0.10, 0.20, and 0.30) volume fractions of methanol at 308.15, 318.15, and 323.15 K are reported. The concentrations are varied from (0.03 to 0.12) mol.l-1 of sodium dodecyl sulphate in presence of ~ 5.0×10-4 mol.l-1 cetyltrimethylammonium bromide. The results showed almost increase in the densities with increasing surfactant mixture concentration, also the densities are found to decrease with increasing temperature over the entire concentration range, investigated in a given mixed solvent medium and these values are found to decrease with increasing methanol content in the solvent composition. The concentration dependence of the apparent molar volumes appear to be negligible over the entire concentration range, investigated in a given mixed solvent medium and the apparent molar volumes increase with increasing temperature and are found to decrease with increasing methanol content in the solvent composition.

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“…In this context, the binding constants of drugs to micelles can be quantitatively determined using the simple mathematical model known as the Benesi–Hildebrand equation based on the Beer–Lambert law valid in the high micelle concentration region (Benesi and Hildebrand, ). In spite of many reports on the interactions between drugs and conventional surfactants in the literature (Azum et al, , ; Cai et al, ; Chauhan et al, ; Enache and Volanschi, ; Hanif et al, ; Hossain and Hoque, ; Kabir‐ud‐Din et al, ; Kaushal et al, ; Khan et al, ; Khan and Shah, ; Lazaro et al, ; Mukhija and Kishore, ; Naqvi et al, ; Noori et al, ; Rub et al, , , ; Sharma and Jani, ; Ullah et al, ), there is limited number of studies that combine spectroscopy with surface tension measurements or conductometry for the understanding of the mechanism of these types of interactions (Ali et al, ; Ansari et al, ; Gokturk et al, ; Kabir‐ud‐Din et al, , ; Maswal et al, ; Rub et al, ). Previously, we reported a study on the binding characteristics of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in the presence of sodium dodecyl sulfate (SDS) and Triton X‐100 (TX‐100) micelles employing spectroscopy and surface tension measurements.…”

Section: Introductionmentioning

confidence: 99%

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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Absorption spectroscopy, conductivity, and surface tension measurements were carried out at 298 K to study the solubilization of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in Aerosol‐OT (AOT) micellar media. The binding constants of SMX and TMP to AOT micelles were determined by applying the Benesi–Hildebrand equation. A comparison of the binding constants indicates that the binding tendency of TMP with AOT micelles is higher than that of SMX. To better analyze the incorporation of drugs into anionic AOT micellar media, surface tension measurements were performed in the presence of SMX and TMP in aqueous media. The influence of TMP and SMX on the surface properties of AOT was determined using the Gibbs Adsorption Isotherm. Changes in the surface properties of AOT determined by surface tension measurements in the presence of drugs are in good agreement with the binding constants determined spectrophotometrically. Calculated surface parameters indicate higher incorporation of TMP with AOT than that of SMX. Comparison of the aqueous solubility of TMP and SMX with micellar media indicated solubility enhancements for both poorly soluble drugs. A special attempt was made to highlight simultaneous interactions of TMP and SMX with AOT using both surface tension and conductometric measurements that can be used to determine counterion‐binding parameters.

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Study of Micellar Behavior of SDS and CTAB in Aqueous Media Containing Furosemide—A Cardiovascular Drug

Cited by 64 publications

References 15 publications

Sound Speed and Density Studies of Interactions Between Cationic Surfactants and Aqueous Gelatin Solution

Sound Speed and Density Studies of Interactions Between Cationic Surfactants and Aqueous Gelatin Solution

Effects of concentration, temperature and solvent composition on density and apparent molar volume of the binary mixtures of cationic-anionic surfactants in methanol–water mixed solvent media

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

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