Study of Microcirculation by Coloured Microspheres and NMR-microscopy in Isolated Rat Heart: Effect of Ischaemia, Endothelin-1 and Endothelin-1 Antagonist BQ 610

Hiller, K. H.; Roder, Fridtjof; Adami, Peter; Voll, Sabine; Kowallik, Peter; Haase, Axel; Ertl, Georg; Bauer, Wolfgang R.

doi:10.1006/jmcc.1997.0538

Cited by 17 publications

(12 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 This method has been validated by the microsphere technique for the isolated rat heart and for in vivo studies. 9,27 In addition, we evaluated MRI of the RBV with an intravascular contrast agent. 13 These data showed a favorable correlation with data for RBV obtained by the MR first-pass technique.…”

Section: Methodsmentioning

confidence: 99%

Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

“…To underline the accuracy of our technique, we refer to the validation against measurements made with microspheres or first pass perfusion imaging in previous studies (6,7,8).…”

Section: Replymentioning

confidence: 99%

Reply

Streif

Hiller

Waller

et al. 2003

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

“…9,10 The number of microspheres (Dye-Trak; Triton Technology Inc; mean diameter 15 m) of 1 color was Ϸ30 000. Microspheres were flushed into the aorta with Krebs-Henseleit buffer containing 0.002% Tween 80 at 0.5 mL per minute over 10 minutes.…”

Section: Perfusion Measurement By Colored Microspheresmentioning

confidence: 99%

Fast High-Resolution Magnetic Resonance Imaging Demonstrates Fractality of Myocardial Perfusion in Microscopic Dimensions

Bauer¹,

Hiller²,

Galuppo³

et al. 2001

Circulation Research

Self Cite

View full text Add to dashboard Cite

Abstract-The fractal nature of heterogeneity of myocardial blood flow and its implications for the healthy and diseased heart is not yet understood. The main hindrance for investigation of blood flow heterogeneity and its role in physiology and pathophysiology is that conventional methods for determination of myocardial perfusion have severe limitations concerning temporal and spatial resolution and invasiveness. In isolated rat hearts, we developed a nuclear magnetic resonance technique that does not depend on contrast agents and in which the apparent longitudinal relaxation time is made perfusion sensitive by selective preparation of the imaging slice. This perfusion-sensitive relaxation time is determined within 40 seconds as a map with a high spatial in-plane resolution of 140ϫ140 m 2 and a thickness of 1.5 mm. Perfusion imaging was validated with the established microsphere technique. Additionally, the congruence between perfusion-sensitive T 1 maps and first-pass perfusion imaging was demonstrated. As an application of high-resolution perfusion imaging, fractal analysis of the spatial distribution of perfusion was performed. We were able to demonstrate that the fractality of this distribution exists even in microscopic dimensions. Vasodilation by nitroglycerin modulated the fractal pattern of perfusion, and the decrease of the fractal dimension indicated a shift toward homogeneity. This implies that parameters of the fractal distribution depend on the microvascular tone rather than on anatomic preformations; ie, fractality is a functional characteristic of perfusion.

show abstract

Study of Microcirculation by Coloured Microspheres and NMR-microscopy in Isolated Rat Heart: Effect of Ischaemia, Endothelin-1 and Endothelin-1 Antagonist BQ 610

Cited by 17 publications

References 2 publications

Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart

Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart

Reply

Fast High-Resolution Magnetic Resonance Imaging Demonstrates Fractality of Myocardial Perfusion in Microscopic Dimensions

Contact Info

Product

Resources

About