Study of midkine protein as prognostic marker for thyroid disease in Al-Najaf City

Abstract

Objectives: The aim of this study is to detection of various thyroid diseases in the early stages and their impact on the metabolic state of the body through the estimation of the Midkine by using ELISA method. Methadology: The current study was conducted on 45 patients with thyroid disease was attending in endocrine and diabetic center in the Al-Sadder Teaching Hospital and Al-Hakim General Hospital in AL-Najaf Province, and 45 healthy person, the samples collected during the period from September 2021 to 2`January. Results: The result of hormonal markers shows high significant with p-value = <0.001 in the level of T3 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. On the other hand, this result was high significant with p-value = <0.001 in the level of T4 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. In addition, this result was high significant with p-value = <0.001 in the level of TSH was higher in Hyperthyroidism compared to Hypothyroidism and the control group. The results of biochemical marker of Midkine was higher in Hyperthyroidism and Hypothyroidism (499.6 ± 120.2 and 489.1 ± 108.1 respectively) compared to and the control group (372.9 ± 92.5).

Evaluation of Midkine Protein in a Sample of Iraqi Patients with Newly Diagnosed Hypothyroidism and Subclinical Hypothyroidism

“…The current findings are in line with the findings of numerous prior research, which found that midkine level concentration was considerably higher in the NDH group compared to the control (Jawad M & Hussein,A..H. 2022). and from complications for hypothyroidism-related cardiovascular disease, MK has been associated with a number of cardiovascular diseases, and many research investigations on cardiovascular diseases have found elevated MK expression.…”