Study of naproxen dissolution in the mixtures of a choline-based deep eutectic solvent + water at different temperatures

Moradi, Milad; Jouyban, Abolghasem

doi:10.1016/j.molliq.2021.117023

Cited by 12 publications

(2 citation statements)

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“…ChCl/EG DES was prepared in a molar ratio of 1:2 by mixixng a certain amount of ChCl and EG, as described with details in our previous work [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

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Solubility of mesalazine in pseudo-binary mixtures of choline chloride/ethylene glycol deep eutectic solvent and water at 293.15 K to 313.15 K

Armani,

Jafari,

Hemmati

et al. 2023

BMC Chemistry

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Mesalazine (5-ASA) is a medication utilized to treat inflammatory bowel diseases involving ulcerative colitis and Crohn’s disease. Mesalazine has fewer side effects but the low solubility and bioavailability of it is responsible for its delayed onset of action. Hence, the goal of this study is to determine the molar solubility of 5-ASA in aqueous pseudo-binary mixtures containing low toxic biocompatible choline chloride/ethylene glycol deep eutectic solvent (ChCl/EG DES) with DES mass fraction of 0.0–1.0 using a shake-flask technique at 293.2–313.2 K and approximately 85 kPa. The experimental results indicated that the solubility of 5-ASA enhanced by addition of DES mass fraction and also increasing temperature. The molarity values of 5-ASA were then modelled by some traditional cosolvency models, and regressed each model parameters. The back-computed molarity of 5-ASA using the selected cosolvency models presented a good consistency with the experimental data (lower mean percentage deviation than 5.14%). Moreover, the Gibbs and van’t Hoff equations were employed to compute the thermodynamic functions of 5-ASA dissolution process in ChCl/EG DES + water from the temperature dependency of solubility data. This analysis presented an endothermic and entropy-driven process of 5-ASA dissolution in ChCl/EG DES + water. Furthermore, enthalpy-entropy compensation analysis represented non-linear enthalpy dissolution vs. Gibbs free energy compensation plots with positive and negative slopes for 5-ASA whereas the positive and negative slopes were probably due to the enhance in solvation of 5-ASA by ChCl/EG DES molecules and the solvent-structure loosing, respectively.

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“…ChCl/EG DES was prepared in a molar ratio of 1:2 by mixixng a certain amount of ChCl and EG, as described with details in our previous work [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

“…( 8 ) [ 35 ] and equation Eq. ( 9 ) [ 33 , 34 , 38 ] are non-linear models for fitting the experimental molar values of 5-ASA in ChCl/EG DES + water mixtures. in these models, and are the model parameters of Eqs.…”

Section: Methodsmentioning

confidence: 99%