2019
DOI: 10.1186/s13063-019-3223-9
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Study of negative pressure wound therapy as an adjunct treatment for acute burns in children (SONATA in C): protocol for a randomised controlled trial

Abstract: Background Although negative pressure wound therapy (NPWT) is widely used in the management of several wound types, its efficacy as a primary therapy for acute burns has not yet been adequately investigated, with research in the paediatric population particularly lacking. There is limited evidence, however, that NPWT might benefit children with burns, amongst whom scar formation, wound progression and pain continue to present major management challenges. The purpose of this trial is to determine w… Show more

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Cited by 13 publications
(11 citation statements)
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“…The trial protocol received approval from the Children's Health Queensland Hospital and Health Service and University of Queensland Human Research Ethics Committees (HREC/17/ QRCH/279, SSA/17/QRCH/292, 2018000335/HREC/ 17/QRCH/279). The methodology has been published previously 18 and the trial was registered with the Australian New Zealand Clinical Trials Registry before the start of recruitment (ACTRN12618000256279).…”
Section: Sonata In C (Study Ofmentioning
confidence: 99%
“…The trial protocol received approval from the Children's Health Queensland Hospital and Health Service and University of Queensland Human Research Ethics Committees (HREC/17/ QRCH/279, SSA/17/QRCH/292, 2018000335/HREC/ 17/QRCH/279). The methodology has been published previously 18 and the trial was registered with the Australian New Zealand Clinical Trials Registry before the start of recruitment (ACTRN12618000256279).…”
Section: Sonata In C (Study Ofmentioning
confidence: 99%
“…Previous studies have found it to be cost-effective in some settings (such as caesarean section incisions in obese women 24 , 25 , diabetic foot ulcers 26 , split-skin grafts for lower limb skin cancer 27 , severe chronic wounds with multiple comorbidities 28 , and pressure ulcers 29 ), but not others (including open fractures and closed surgical wounds of the lower limb 30 , 31 ). This study was performed to investigate the cost-effectiveness of adjunctive NPWT in the treatment of small-area burns in children, using evidence from the Study Of Negative pressure wound therapy as an Adjunctive Treatment for Acute burns in Children (SONATA in C) randomised controlled trial 32 , 33 .…”
Section: Introductionmentioning
confidence: 99%
“…Negative pressure wound fluid samples were collected from patients enrolled in a two‐arm, prospective, randomized controlled trial investigating the efficacy of adjunctive NPWT in the acute management of small‐area paediatric thermal burns. The trial's protocol and results have been published previously 9,10 . Briefly, children presenting with burns covering less than 5% of their total body surface area (TBSA) within 7 days of injury were randomized to either standard silver‐impregnated dressings consisting of Acticoat (Smith & Nephew, Hull, UK) with Mepitel (Mölnlycke Healthcare, Mikkeli, Finland), or these same dressings in conjunction with NPWT.…”
Section: Methodsmentioning
confidence: 99%
“…The trial's protocol and results have been published previously. 9,10 Briefly, children presenting with burns covering less than 5% of their total body surface area (TBSA) within 7 days of injury were randomized to either standard silver-impregnated…”
Section: Patient Recruitment and Sample Collectionmentioning
confidence: 99%