Study of new capacities in the evaluation of glycemic control in patients with type 2 diabetes

Abstract

The purpose of the study was to comprehensively analyze glycemic control in type 2 diabetes (T2D) patients who were first given glucose-reducing therapy. Glidiab MB and Diabeton MB caused a comparable reduction in glycemic control parameters: the level of HbA1c, fasting glycemia, and mean glycemic levels as shown by the results of its continuous glucose monitoring system (CGMS) study. The lower glycemic level was not accompanied by weight gain and it improved lipid spectrum parameters. The readings of monthly self-control of glycemia were transformed to its deviation from the goal range (ADRR) that and the hyper- and hypoglycemia indices calculated from the continuous glycemic control were used to evaluate glycemic lability not reflected by HbA1c. In this connection ADRR may be used to evaluate the efficiency of sugar-reducing therapy and in the examined groups it proved to be low, which generally reflects the stable course of the disease in new cases of T2D. The mean glycemic value calculated from CGMS data virtually coincides with the mean glycemia estimated from glycemic self-control readings both on the day of continuous glucose monitoring and in the month to come before and after CGMS study. In this connection the latter is justified only when the continuous glycemic curve undergoes a complex analysis. The complex analysis of the continuous glycemic curve includes symmetrization of the continuous glycemia scale; calculation of hyper- and hypoglycemic indices, hourly diurnal hyperglycemic index and hourly glycemic variations (Poincare method). The use of this procedure could compare the glucose-reducing effect of the two drugs within the framework of a short-term study.

Concerning Space Distribution of the Soft X-Ray Emissivity in the U-3M Torsatron

“…On the base of previous estimations [4], in order to increase signal amplitude a thin 2 µm Al foil was installed on the U-3M SXR pinhole slit. Soft X-ray emission in the plasma includes free-bound recombination radiation; the bound-bound line radiation introducing photons in the low energy range.…”

“…1. The dependence was obtained by numerical integration using recent μ/ρ data, as it is described in [4]. The photodiode array IRD AXUV-20EL, used as a detector part, has almost flat energy dependence in the 0.2…4000 eV photon energy range.…”

“…Such a long distance defines significant SXR brightness decay (proportional to the square of this distance). Initially designed for the U-2M torsatron [4] the SXR diagnostics has been adopted for rather unusual U-3M conditions. In order to increase the SXR brightness in 25-50 times the pinhole camera is placed between helical coils near the plasma.…”