Study of new β-lactams-substituted s-triazine derivatives as potential bioactive agents

Abstract

In our continuous effort toward synthesis of potential bioactive agents, two series of benzonitriles/ nicotinonitriles endowed with b-lactams bound to s-triazine skeleton were synthesized by applying an efficient palladium catalyzed C-C Suzuki coupling reaction. The synthesized compounds were screened for their in vitro antimicrobial against different human pathogenic microorganisms and prostate cancer PC3 cells. Some compounds displayed remarkable antimicrobial activity and noticeable anticancer activity. It was observed that both benzonitrile and nicotinonitrile sets are essential to increase the different pharmacological activities. The new synthesized compounds were characterized by FT-IR, 1 H NMR, 13 C NMR, and MS analysis.

Synthesis, molecular docking, ADME study, and antimicrobial potency of piperazine based cinnamic acid bearing coumarin moieties as a DNA gyrase inhibitor

“…Our research group has extensively synthesized antimicrobial scaffold. [ 3–5 ] To overcome this concern, the concept of molecular hybridization appears as an effective strategy to increase the hybrid molecule's biological activity or pharmacological efficacy. [ 6,7 ] In this context, Coumarins exhibit various biological activities, [ 8–10 ] antioxidant, [ 11,12 ] anti‐HIV, [ 13 ] anticancer, [ 14 ] anti‐inflammatory, [ 15 ] antibacterial, [ 16 ] anticoagulant [ 17,18 ] and cinnamic acids exhibit various biological activities [ 19 ] and attracted due to their antioxidant, [ 20 ] antimicrobial, [ 21 ] anticancer, [ 22 ] and anti‐inflammatory [ 23 ] activity.…”

Staudinger ketene–imine [2+2] cycloaddition of novel azomethines to synthesize biologically active azetidinone derivatives and their in vitro antimicrobial studies

“…Azomethines-derived azetidinones are considered as special ligand competitors in natural, therapeutic, and pharmaceutical applications [58,59]. Along these lines, in association of generally applications for heterocyclic cycloaddition compounds containing azomethine group as tests for biomolecules in medicinal, biophysical, and bioanalytical science [60], thus, we have synthesized and characterized new series of azomethine compounds derived from p-dimethyl amino cinnamaldehyde (p-DMAC) and primary aromatic amines.…”