Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2

Abstract

Introduction: Omentin-1, is an adipokine, inhibits TNF-induced inflammation of vascular smooth muscle cells, so its decreased levels in plasma of patients with coronary artery disease (CAD), indicated that omentin-1 may also be involved in the occurrence of CAD. Objective: Study the alternation of plasma levels of omentin-1 and chemerin in patients with coronary artery diseases. Patients and methods: This case-control study was carried out on 120 patients with coronary artery disease and 50 healthy volunteers, in the period from January 2018 to June 2019, divided into control group: 50 healthy volunteers, stable angina pectoris group: 60 cases, acute coronary syndrome (ACS) group: 60 cases, which were subclassified into; (a) 20 unstable angina (USA) cases; (b) 20 segment elevation myocardial infarction (STEMI) cases; (c) 20 non ST segment elevation myocardial infarction (NSTEMI) cases. Results: There was a highly significant difference between the studied groups in hsCRP, omentin-1 and chemerin levels with significant difference in SA group and ACS groups compared to control group. Regarding acute coronary syndrome (ACS) groups, there was significant difference in hsCRP between USA and infarction groups. Chemerin showed significant difference between USA and STEMI and USA and Non STE MI. While omentin-1 showed no significant difference between ACS subgroups. Regarding CAD without DM type2 and CAD with DM type2. There was high statistical significant difference between the groups as regarding FBG, HbA1c, total cholesterol (T. Chol), HDL-C, LDL-C, hsCRP, chemerin and omentin-1. Conclusion: increasing total cholesterol, triglycerides, LDL-C, high-sensitivity C-reactive protein (hsCRP) and chemerin. Decreasing HDL-C and Omentin-1 are independent predictors of CAD in type 2 diabetic patients.