Study of oxytocin receptor in human myometrium using highly specific 3H-labeled oxytocin.

Sakamoto, Hideki; Den, K.; Yamamoto, Kōichi; Arai, Takaaki; Kawai, Shun; Oyama, Yoichi; Yoshida, Takao; Takagi, Shigeo

doi:10.1507/endocrj1954.26.515

Cited by 8 publications

(1 citation statement)

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“…These results suggest that the maternal plasma OT level is not the only trigger for initiation of labor. As suggested by Soloff et al (1) (13) based on studies on uterine receptor in rats, changes in human uterine OT receptor may also be involved in determining the onset of labor (12). In the anencephalic cases the maternal plasma OT level was 13.4k8.0 pU/ml, which was no different from that in normal spontaneous parturition, but the OT levels in UA and UV plasma were not detectable.…”

Section: Discussionmentioning

confidence: 80%

Feto‐Maternal Plasma Oxytocin Levels in Normal and Anencephalic Pregnancies

Otsuki

Takahashi

Yamaji

et al. 1983

Acta Obstet Gynecol Scand

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In 4 women with anencephalic fetuses, the oxytocin level was measured in the maternal plasma in the second stage of labor and in the umbilical artery (UA) and umbilical vein (UV) by radioimmunoassay (RIA). In these cases, the mean maternal OT level was 13.4 +/- 8.0 microU/ml (mean +/- S.E.), which was not significantly different from the OT levels in cases of normal spontaneous birth and elective cesarean section. The UA and UV plasma OT levels in these cases were below the detectable level (less than 2 microU/ml), whereas in normal spontaneous births, they were 18.2 +/- 4.9 microU/ml and 12.2 +/- 2.3 microU/ml, respectively. The OT level in the UA was higher than that in the UV. There was no difference between the mean OT levels in patients with, versus those without contractions, but the plasma OT levels in the second stage of labor were higher than those in the first stage. In normal pregnancies the plasma OT concentration increased during parturition. These results suggest that placental transfer of maternal plasma OT to the fetal circulation is limited, and that in cases of anencephalic fetuses, maternal labor does not necessarily require fetal OT as a trigger or for its maintenance.

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Section: Discussionmentioning

confidence: 80%