Study of PDMS characterization and its applications in biomedicine: A review

Victor, A. de Oliveira; Ribeiro, J. F.; Araújo, Fernando F.

doi:10.24243/jmeb/4.1.163

Cited by 120 publications

(74 citation statements)

References 25 publications

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“…Ltd., Osaka, Japan) were sterilized under UV light for overnight inside a hood. Atmospheric plasma was applied to both tortuous microchannels and cover glass for 2 min to improve cell and immobilize soluble factors [ 26 , 27 , 28 , 29 ]. The tortuous microchannels were inverted and attached to the glass.…”

Section: Methodsmentioning

confidence: 99%

Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices

et al. 2020

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Collective cell migration is an essential phenomenon in many naturally occurring pathophysiological processes, as well as in tissue engineering applications. Cells in tissues and organs are known to sense chemical and mechanical signals from the microenvironment and collectively respond to these signals. For the last few decades, the effects of chemical signals such as growth factors and therapeutic agents on collective cell behaviors in the context of tissue engineering have been extensively studied, whereas those of the mechanical cues have only recently been investigated. The mechanical signals can be presented to the constituent cells in different forms, including topography, substrate stiffness, and geometrical constraint. With the recent advancement in microfabrication technology, researchers have gained the ability to manipulate the geometrical constraints by creating 3D structures to mimic the tissue microenvironment. In this study, we simulate the pore curvature as presented to the cells within 3D-engineered tissue-scaffolds by developing a device that features tortuous microchannels with geometric variations. We show that both cells at the front and rear respond to the varying radii of curvature and channel amplitude by altering the collective migratory behavior, including cell velocity, morphology, and turning angle. These findings provide insights into adaptive migration modes of collective cells to better understand the underlying mechanism of cell migration for optimization of the engineered tissue-scaffold design.

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Section: Methodsmentioning

confidence: 99%

Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices

et al. 2020

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“…Most UTDs are fabricated with silicone-based polymers such as poly(dimethylsiloxane) (PDMS) [10]. Despite its attractive properties, including the high mechanical and chemical stability and low toxicity, PDMS is extremely hydrophobic and, like the majority of the coating materials, is susceptible to bacteria and fungi adhesion [11,12]. In fact, UTDs are very prone to microbial adhesion and, consequently, biofilm formation, which is the leading cause for most UTIs.…”

Section: Introductionmentioning

confidence: 99%

Optimizing CNT Loading in Antimicrobial Composites for Urinary Tract Application

Gomes

Teixeira‐Santos

et al. 2021

Applied Sciences

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Several methodologies have been implemented with the intent of preventing or reducing the formation of biofilms on indwelling urinary devices. The use of carbon nanotubes (CNTs) in the biomedical field has been increasing, particularly in the production of antimicrobial and antifouling coatings. Despite their proven antimicrobial properties, their use as coating materials for urinary tract devices (UTDs) is still poorly documented. In the present work, CNT/poly(dimethylsiloxane) (PDMS) composite materials containing different CNT loadings were prepared and further tested against Escherichia coli under conditions prevailing in UTDs. Besides CNT loading optimization, textural modifications were also introduced on the surface of CNTs to improve the antibiofilm pro-perties of the final composites. Material characterization included the textural evaluation of CNTs and the assessment of surface morphology by scanning electron microscopy, while the surface hydrophobicity was determined by contact angle measurements. Biofilm analysis was performed by determining the number of culturable and total cells and by confocal laser scanning microscopy. Results revealed that, by filling the PDMS matrix with 3 wt% CNT loading, a significant reduction in cell culturability (39%) can be achieved compared to PDMS. Additionally, the textural modifications induced by ball-milling treatment proved to be effective on the inhibition of biofilm formation, reducing the amount of biofilm per surface area, biofilm thickness and surface coverage in 31, 47 and 27%, respectively (compared to surfaces where CNTs were not ball-milled).

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“…Nowadays, polymers and elastomers have been attracting the attention of many researchers with its performance in the daily and environmental life of the planet due to their wide range of chemical and physical properties and excellent characteristics such as flexibility and corrosion resistance [1]. Among polymers, there is an increasing interest in the study of polydimethylsiloxane (PDMS) for applications such as mechanical and civil engineering, electronic devices, and in biomedical fields [2][3][4][5][6][7]. Within these areas, applications were reported such as water/oil and gas filtration membranes [8][9][10], sensors [11][12][13], lubricants [14], sealing agents [15], blood analogues [16][17][18], and also for microfluidic devices [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Composite Material of PDMS with Interchangeable Transmittance: Study of Optical, Mechanical Properties and Wettability

et al. 2021

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Polydimethylsiloxane (PDMS) is a polymer that has attracted the attention of researchers due to its unique properties such as transparency, biocompatibility, high flexibility, and physical and chemical stability. In addition, PDMS modification and combination with other materials can expand its range of applications. For instance, the ability to perform superhydrophobic coating allows for the manufacture of lenses. However, many of these processes are complex and expensive. One of the most promising modifications, which consists of the development of an interchangeable coating, capable of changing its optical characteristics according to some stimuli, has been underexplored. Thus, we report an experimental study of the mechanical and optical properties and wettability of pure PDMS and of two PDMS composites with the addition of 1% paraffin or beeswax using a gravity casting process. The composites’ tensile strength and hardness were lower when compared with pure PDMS. However, the contact angle was increased, reaching the highest values when using the paraffin additive. Additionally, these composites have shown interesting results for the spectrophotometry tests, i.e., the material changed its optical characteristics when heated, going from opaque at room temperature to transparent, with transmittance around 75%, at 70 °C. As a result, these materials have great potential for use in smart devices, such as sensors, due to its ability to change its transparency at high temperatures.

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Study of PDMS characterization and its applications in biomedicine: A review

Cited by 120 publications

References 25 publications

Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices

Effect of Geometric Curvature on Collective Cell Migration in Tortuous Microchannel Devices

Optimizing CNT Loading in Antimicrobial Composites for Urinary Tract Application

Composite Material of PDMS with Interchangeable Transmittance: Study of Optical, Mechanical Properties and Wettability

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