Study of Performance Characteristics of TSH on Finecare™ Poct Device

Abstract

Objective: Thyroid diseases can be diagnosed and monitored by serum thyroid stimulating hormone (TSH) measurement along with serum T3 and T4 (both free and total). However, TSH is used to distinguish between euthyroid and hyperthyroid patients. Hence, analysis sensitivity of the TSH assay plays a very significant role. Aims and objectives – The aim of the study was to perform the precision study, calculate the randomerror and analytical measurement rangeverification, as well as verify the accuracy of TSH estimation on Finecare™ point of care testing (POCT). Methods: The experimental evaluation was done in preliminary and final parts. The preliminary part calculates random errors, systemic errors, and recovery whereas the final evaluation comprises the implementation of the method comparison between chemiluminescence and immunofluorescence assay (CLIA). Results: In the preliminary evaluation, the inter-assay-high-value sample had CV% was 15 whereas the low-value sample has 13, and the intra-assay had a CV% of 5.8. The recovery test shows 22.22% CV. The final evaluation of the new method Immuno Fluorescence Assay and reference method (CLIA) has a correlation of coefficient 0.9937. Conclusion: POCT reduces pre-analytical error by reducing misidentification of the patient, specimen, and sample handling. This reduces the turn-around time. It helps to improve the quality of care, healthy outcomes, and affordability.

Exploring the Transformative Potential of In Situ Gels: An Overview of Thermosensitive and pH‐Sensitive Gel Systems for Biomedical Applications

“…This approach allows for synergistic effects, improved therapeutic outcomes, and reduced dosages of individual drugs. Bioactive in situ gels : Incorporation of bioactive molecules, such as growth factors, cytokines, or gene therapies, into in situ gels can enhance tissue regeneration and promote healing in various applications, including wound healing, bone repair, and tissue engineering. [ 71 ] Industrial potentials [ 72–76 ] :In situ gels have a large industrial potential, particularly in the pharmaceutical and biomedical sectors. Among the most important industrial applications are:Drug Delivery Systems: In situ gels provide a promising platform for controlled drug delivery, allowing therapeutic chemicals to be released continuously at the target site.…”