Study of pertussis vaccines in infants: Comparison of response to acellular pertussis DTP vaccines containing 25 μg of FHA and either 25 or 8 μg of

BackgroundRoutine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse e ects. Following this action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as e ective, but less reactogenic than the whole-cell vaccines. This is an update of a Cochrane review first published in 1999, and previously updated in 2012. In this update, we included no new studies. ObjectivesTo assess the e icacy and safety of acellular pertussis vaccines in children and to compare them with the whole-cell vaccines.

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Acellular vaccines for preventing whooping cough in children

Zhang

Prietsch

Axelsson

et al. 2011

Cochrane Database of Systematic Reviews

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Background Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse e ects. Following this action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as e ective, but less reactogenic than the whole-cell vaccines. This is an update of a Cochrane review first published in 1999, and previously updated in 2012. In this update, we included no new studies. Objectives To assess the e icacy and safety of acellular pertussis vaccines in children and to compare them with the whole-cell vaccines.

show abstract

Study of pertussis vaccines in infants: Comparison of response to acellular pertussis DTP vaccines containing 25 μg of FHA and either 25 or 8 μg of

Cited by 13 publications

References 18 publications

Acellular vaccines for preventing whooping cough in children

Acellular vaccines for preventing whooping cough in children

Acellular vaccines for preventing whooping cough in children

Acellular vaccines for preventing whooping cough in children

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