Study of pharmacological activities of methanol extract of Jatropha gossypifolia fruits

Abstract

Objective:The present study was carried out to investigate the possible in vivo analgesic, neuropharmacological and anti-diarrheal activities of the methanol extract of Jatropha gossypifolia fruits.Materials and Methods:The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuropharmacological activities were evaluated by hole cross, hole-board, and elevated plus-maze (EPM) tests and the anti-diarrheal activity was assessed by castor oil induced diarrhea inhibition method.Findings:The extract showed highly significant (P < 0.001) analgesic activity with % inhibitions of writhing response at doses 200 and 400 mg/kg body weight were 77.86% and 71.25%, respectively. The extract at both doses showed significant (P < 0.05) sedative effect in-hole cross test. In-hole board test, the extract showed highly significant (P < 0.001) anxiolytic activity at lower dose whereas this activity was observed at higher dose in EPM test. The extract also showed highly significant (P < 0.001) anti-diarrheal activity.Conclusion:The findings of the study clearly indicate the presence of significant analgesic, neuropharmacological and anti-diarrheal properties of the plant, which demands further investigation including, compound isolation.

Jatropha gossypiifolia L. (Euphorbiaceae): A Review of Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of This Medicinal Plant

“…In hole board test, the extract showed highly significant anxiolytic activity at a dose of 200 mg/kg, whereas the same activity was observed at 400 mg/kg dose in elevated plus-maze test [111]. Similar results were observed in the methanolic extract from fruits [110]. …”

Determination of phenolic and triterpenic compounds in Jatropha gossypiifolia L by Ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS)

“…The fruit is capsular, with three furrows, containing a dark seed with black spots (Félix-Silva et al, 2014). Regarding its phytochemical constitution, alkaloid, steroids, saponin, lignan, tannin, phenolic compounds, flavonoid, curcin, triterpenes, diterpene, jatrophone, jatropholones A and B, jatrophatrione, apigenin, and cyclogossine A have been reported in different extracts from different parts of this plant (Apu et al, 2013;Félix-Silva et al, 2014;Khyade, Vaikos, 2011;Saini et al, 2015).…”

Sodium metavanadate induced cognitive decline, behavioral impairments, oxidative stress and down regulation of myelin basic protein in mice hippocampus: Ameliorative roles of β‐spinasterol, and stigmasterol

“…In several studies compounds from plants have been shown to have anxiolytic activity (Gadekar, Sourabh, & Jitender, ; Herrera‐Ruiz, Román‐Ramos, Zamilpa, Tortoriello, & Jiménez‐Ferrer, ; Sandeep & Suresh, ). Their anxiolytic effect has been attributed to its effect on gamma‐amino‐butyric‐acid (GABA), receptors in the CNS (Apu, Hossain, Rizwan, Bhuyan, & Jamaluddin, ) which may be the mechanism through which stigmasterol acts. This study provides experimental/scientific support for the folklore use of G. carpinifolia in the management of anxiety.…”