Study of photoradiation therapy by intra-arterial injection of HpD

Andou, Takashi; Sekimoto, Ikufumi; Hoshiyama, Naoki; Kojima, Takao; Katou, Takahiro; Okuda, Junichi; Ida, Kazunori; Morita, Yutaka; Itani, Kenji; Yoshikawa, Toshikazu; Kondou, Motoharu

doi:10.2530/jslsm1980.7.3_143

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1995

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“…Unfortunately, the photosensitizer pharmacokinetics and distribution in man are still unknown (17); however, an experimental study in dogs revealed that intra-arterial injection of Photofrin achieved higher Photofrin accumulation than intravenous injection (18). Kostron et al (19) reported the effectiveness of PDT with intra-arterial injection of Photofrin for brain tumors.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy of Lung Cancer With Bronchial Artery Infusion of Photofrin

Okunaka

Kato

Konaka

et al. 1995

Diagnostic and Therapeutic Endoscopy

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Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the hospitalization period, we recently gave reduced doses of Photofrin by bronchial arterial infusion. Five patients with endoscopically evaluated minimally invasive carcinoma of the lung were given 0.7 mg/kg of Photofrin by bronchial arterial infusion 48 hr before PDT. Complete remission was obtained in all 5 cases and no case showed skin photosensitivity when exposed to sunlight under careful surveillance at one week after PDT.

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Section: Discussionmentioning

confidence: 99%