Study of possible association between endometriosis and phthalate and bisphenol A by biomarkers analysis

Fernandez, Miriany Avelino Moreira; Cardeal, Zenilda de Lourdes; Carneiro, Márcia Mendonça; André, Leiliane Coelho

doi:10.1016/j.jpba.2019.04.048

Cited by 30 publications

(27 citation statements)

References 25 publications

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“…Four papers were excluded for the following reasons: two papers did not meet the inclusion criteria [ 47 , 48 ]; Huang et al were excluded because adenomyosis and endometriosis were merged in the same group [ 49 ] and another paper was excluded because the control group included women with stage I endometriosis [ 50 ]. Thus, 14 articles [ 40 , 41 , 51 – 62 ] were included in the quantitative and qualitative analyses (Figure 1 ). Noteworthy, Buck Louis et al [ 57 ] included operative and population cohorts that were counted as 2 separate studies for the analysis of urinary compounds.…”

Section: Resultsmentioning

confidence: 99%

“…The results of Sun et al [ 59 ] were evaluated only qualitatively due to the absence of variability measurement (e.g., standard deviations). The quantitative OR analysis only included studies in which there was a comparison between women with and without endometriosis [ 55 , 57 , 59 , 62 ]. ORs from Upson et al [ 41 ] and Weuve et al [ 54 ] were only evaluated qualitatively since the comparison was between different quartiles of exposure (i.e., first vs. fourth quartiles).…”

Section: Resultsmentioning

confidence: 99%

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Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Conforti

Carbone

Simeon

et al. 2021

J Assist Reprod Genet

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Purpose Endometriosis is a chronic debilitating inflammatory pathology which interests females in their reproductive age. Its pathogenesis has not yet been clearly defined. Recent evidence linked chemical agents as endocrine-disrupting chemicals to endometriosis. Phthalates are a widely used class of such compounds. This study aimed to summarize the current literature evaluating the link between exposure to phthalates and occurrence of endometriosis. Methods A systematic review of literature and meta-analysis has been carried out following PRISMA guidelines to assess such link. Fourteen studies have been included in the review. Risk of bias has been assessed through the Newcastle Ottawa Scale. Results We observed association between endometriosis and increased urinary levels of MBP/MnBP, MEOHP, and MEHHP, but not for others. Blood-derived analysis showed statistically significant link between endometriosis and BBP, DEHP, DnBP, and MEHP. Conclusion Given the wide heterogeneity of included studies, results should be taken with caution. Further studies with more rigorous methodology are encouraged to unravel the true link between this class of toxic compounds and manifestation of endometriosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Conforti

Carbone

Simeon

et al. 2021

J Assist Reprod Genet

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“…Kim conducted a prospective case-control study in Korea and noted MEHHP and MEOHP played important roles in the risk of endometriosis [32]. However, several studies presented conflicting results [29,39]. Therefore, these results need to be further verified.…”

Section: Discussionmentioning

confidence: 99%

Association between Phthalate Metabolites and Risk of Endometriosis: A Meta-Analysis

Cai

Yang

Liu

et al. 2019

IJERPH

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Objective: The association between phthalates and endometriosis risk is inconclusive. This meta-analysis aims to evaluate the association between five different phthalate metabolites and endometriosis, based on current evidence. Methods: The literature included PubMed, WOS (web of science), and EMBASE, published until 3 March 2019. We selected the related literature and evaluated the relationship between phthalates exposure and endometriosis risk. All statistical analyses were conducted with STATA version 12.0. Results: Data from eight studies were used in this review. The results of this analysis showed that mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) exposure was potentially associated with endometriosis (OR = 1.246, 95% CI = 1.003–1.549). We have not found positive results in mono(2-ethylhexyl) phthalate (MEHP), monoethyl phthalate (MEP), monobenzyl phthalate (MBzP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) analyses (MEHP: OR = 1.089, 95% CI = 0.858–1.383; MEP: OR = 1.073, 95% CI = 0.899–1.282; MBzP: OR = 0.976, 95% CI = 0.810–1.176; MEOHP: OR = 1.282, 95% CI = 0.874–1.881). In subgroup analyses for regions, the associations were significant between MEHHP and endometriosis in Asia (OR = 1.786, 95% CI = 1.005–3.172, I² = 0%), but not in USA (OR = 1.170, 95% CI = 0.949–1.442, I² = 45.6%). Conclusions: Our findings suggested a potential statistical association between MEHHP exposure and endometriosis, particularly, the exposure of MEHHP might be a potential risk for women with endometriosis in Asia. However, positive associations between the other four Phthalate acid esters (PAEs) and endometriosis was not found. Given the weak strength of the results, well-designed cohort studies, with large sample sizes, should be performed in future.

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“…Endometriosis can be harmful to granulosa cells (Sanchez et al, 2016) Overall, studies are consensual that phthalates exposure, mainly DEHP, may be a risk factor for endometriosis (Cai et al, 2019;Kim et al, 2015;Wen et al, 2019). However, there are still some limitations in understanding the pathophysiology of phthalates in endometriosis (Kim & Kim, 2020;Moreira Fernandez et al, 2019), and therefore more studies are needed.…”

Section: Endometriosismentioning

confidence: 99%

Update about the disrupting‐effects of phthalates on the human reproductive system

Mesquita

Lorigo

Cairrão

2021

Molecular Reproduction Devel

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Phthalate esters are synthetic chemicals used in the plastic industry as plasticizers and consumable products. According to United Nations, about 400 million tons of plastic are produced every year. In parallel with increased production, the concerns about its effects on human health have increased because phthalates are endocrinedisrupting compounds. Humans are continuously exposed to phthalates through different routes of exposure. Experimental data have associated the phthalates exposure to adverse effects on development and reproduction in women (e.g., earlier puberty, primary ovarian insufficiency, endometriosis, preterm birth, or in vitro fertilization) and men (e.g., anogenital distance, cryptorchidism, hypospadias, and changes in adult reproductive function) although there is no consensus. Therefore, one question arises: could the increase in infertility be related to phthalates exposure? To answer this question, we aimed to assess the disruptingeffects of phthalates on the human reproductive system. For this, we reviewed the current literature based on epidemiological and experimental data and experimental studies in humans. The phthalate effects were discussed in a separate mode for female and male reproductive systems. In summary, phthalates induce toxicity in the reproductive system and human development. The increased plastic production may be related to the increase in human infertility.

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Study of possible association between endometriosis and phthalate and bisphenol A by biomarkers analysis

Cited by 30 publications

References 25 publications

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature

Association between Phthalate Metabolites and Risk of Endometriosis: A Meta-Analysis

Update about the disrupting‐effects of phthalates on the human reproductive system

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