Study of possible role of CYP1A1, GSTT1, GSTM1, GSTP1, NAT2 and ADRB2 genes polymorphisms in bronchial asthma development in children

Tatarskyy, Pavel; Chumachenko, N. G.; Kucherenko, A. M.; Gulkovskyi, R. V.; Arabskaya, L.P.; Smirnova, Olga A.; Tolkach, S. I.; Antipkin, Yu.G.; Livshits, L. A.

doi:10.7124/bc.000084

Cited by 11 publications

(4 citation statements)

References 17 publications

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“…Therefore, 59 articles were identified for further study. Of these 59 articles, four [17] – [20] were excluded as they were conference abstracts, seven [12] , [21] – [26] did not report useable data, and one [27] was excluded because the full text was not available. In addition, one article [28] was excluded as it was in Polish.…”

Section: Resultsmentioning

confidence: 99%

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

et al. 2014

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Background and ObjectiveA number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.MethodsA literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.ResultsArg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179–2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417–0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434–0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768–0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).ConclusionsNone of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.

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Section: Resultsmentioning

confidence: 99%

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

et al. 2014

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“…Of the remaining 36 articles, four articles were excluded for being conference abstracts, four articles did not report usable data, two articles had overlapping data so the smaller study was excluded, and one article was excluded due to a specialized population (both cases and controls were selected based occupational exposure). Thus, a total of 26 case–control studies met inclusion criteria and were included in the current meta‐analysis (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

“…included a total of 16 studies, one of which was a cross‐sectional study that was not included in the current meta‐analysis. In addition, four articles included in our meta‐analysis were not part of the study by Zhao Y. et al . Furthermore, in the study by Zhao Y. et al ., two articles considered to describe an adult population in our study only used extracted data from children.…”

Section: Discussionmentioning

confidence: 99%

Significant association between asthma risk and the GSTM1 and GSTT1 deletion polymorphisms: An updated meta‐analysis of case–control studies

et al. 2013

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Polymorphisms in GSTM1 and GSTT1 may be associated with asthma risk, yet several studies and metaanalyses have reported inconclusive results. Therefore, an updated meta-analysis was conducted. Literature searches were performed using the Pubmed, Embase and Web of Science databases until October 2012. Variant 'null' genotype was compared with wild-type 'present' in the pooled data. All statistical analyses were performed using STATA 11.0. A total of 26 casecontrol studies were suitable for inclusion in the metaanalysis. In the overall population, a significant association was found for both the GSTM1 (odds ratio (OR) = 1.452; 95% confidence interval (CI): 1.192-1.770) and GSTT1 polymorphism (OR = 1.792; 95% CI:1.293-2.483). For subgroup analysis by age, GSTM1 significantly increased risk for both children (OR = 1.368; 95% CI: 1.051-1.781) and adults (OR = 1.859; 95% CI: 1.183-2.921). For GSTT1, a significant association was only found in the adult population (OR = 2.312; 95%CI: 1.204-4.439). Based on subgroup analysis by ethnicity, a significant association for GSTM1 was found in Europe (OR = 1.303; 95% CI: 1.018-1.667), Africa (OR = 2.175; 95%CI: 1.560-3.031) and Latin America (OR = 2.265; 95%CI: 1.375-3.729). For GSTT1, significantly increased risk was found only for Asian (OR = 2.105; 95% CI: 1.101-4.025) and Russian (OR = 2.747; 95% CI: 1.071-7.046) populations. This metaanalysis provides evidence that GSTM1 and GSTT1 polymorphisms may be risk factors for asthma.

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“…Initially, there were 386 potentially relevant publications identified during the literature search. Following primary screening using the study exclusion criteria, a total of 167 publications were eliminated, which resulted in a total of 18 controlled studies that included 2,982 pediatric patients with asthma and 2,651 controls [10,15–17,22–35]. The main findings of each study are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

The C79G Polymorphism of the β2-Adrenergic Receptor Gene, ADRB2, and Susceptibility to Pediatric Asthma: Meta-Analysis from Review of the Literature

Zhang

Zhu

2019

Med Sci Monit

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Background The ADRB2 gene encodes the β2-adrenergic receptor (β2-AR). This study aimed to determine the association between the C79G polymorphism of the ADRB2 gene and its association with pediatric asthma using a meta-analysis of the published data. Material/Methods Review of publications up to May 2018 was from the PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and WanFang databases. The odds ratio (ORs) with 95% confidence interval (CI) were used in evaluating the strength of the reported association between the C79G polymorphism of the ADRB2 gene and pediatric asthma. Results There were 18 controlled studies that included 2,982 pediatric cases of asthma and 2,651 controls. Expression of the C79G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs . CC: OR, 0.69; 95% CI, 0.55–0.88) and the recessive model (GG vs . CC+CG: OR, 0.65; 95% CI, 0.53–0.81). Subgroup analysis by ethnicity showed a significantly reduced risk of pediatric asthma in Asian patients for comparison of the co-dominant model (GG vs . CC: OR, 0.59; 95% CI, 0.45–0.78), the recessive model (GG vs . CC+CG: OR, 0.58; 95% CI, 0.45–0.76), and the allelic model (G vs . C: OR, 0.89; 95% CI, 0.79–0.99). Conclusions The C79G polymorphism of the ADRB2 gene encoding β2-AR was associated with a reduced risk for the development of pediatric asthma, particularly in the Asian population.

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Study of possible role of CYP1A1, GSTT1, GSTM1, GSTP1, NAT2 and ADRB2 genes polymorphisms in bronchial asthma development in children

Cited by 11 publications

References 17 publications

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

Significant association between asthma risk and the GSTM1 and GSTT1 deletion polymorphisms: An updated meta‐analysis of case–control studies

The C79G Polymorphism of the β2-Adrenergic Receptor Gene, ADRB2, and Susceptibility to Pediatric Asthma: Meta-Analysis from Review of the Literature

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