Study of Post Compression Parameters of Various Marketed Paracetamol Tablets in India

Nayak, Shashank; Rakshita, AS; Shwetha, Sankepally; Kamath, Kratika

doi:10.29161/pt.v7.i2.2019.35

Cited by 4 publications

(2 citation statements)

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“…Various studies conducted in Malaysia, Palestine, Pakistan, Bangladesh, and India have investigated brands of paracetamol and fulfilled the requirements on USP for disintegration time. 3,7,[19][20][21] Dissolution was another parameter directly related to the absorption and bioavailability of the drug. Drugs with poor dissolution profiles will not be sufficiently available in the body to produce the desired therapeutic outcome.…”

Section: Discussionmentioning

confidence: 99%

In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia

Abebe¹,

Beressa²,

Yimer³

2020

DHPS

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Background The aim of this research was to evaluate quality control parameters of available brands of paracetamol tablets in Gondar city since standard quality parameters are essential for a better quality of the product. The different brands of paracetamol tablets were obtained from local pharmacies in Gondar town and the University of Gondar (UOG) hospital pharmacies. Methods Five brands of paracetamol, from each, 102 tablets were collected from private pharmacies, government health centers, and UOG pharmacies. The popular brands in the city, Panadol, Para-denk, Paramol, Paracetamol (EPHARM), and Cadimol, conventional tablets of 500 mg strength were chosen and the tablets were assessed for different quality parameters: weight variation, hardness, friability, disintegration, dissolution, and drug content (assay) using compendial methods. The tablets were evaluated to check if they comply with the specifications of USP (United States Pharmacopeia). Results From the results, it was observed that all the brands of paracetamol have passed the tests and met the specifications of USP. Results of weight variation, hardness, friability, and disintegration time ranged from 0.46 to 1.11%, 117.0 to 174.70 N, 0.07 to 0.63%, and 01 to 08 minutes for all the tablets, respectively. The dissolution profiles of all the brands are within the acceptable label claim. The assay results showed that the drug content of the paracetamol brands ranged from 95.04% to 106.81%. The dissolution rate was significantly different (p < 0.05) as compared to code 1 with all brands tested at 30 minutes. The disintegration time of different brands was also significantly different from the comparator (code 1) except code 2. Conclusion Based on the finding from this study, there were no significant deviations from pharmacopeia standards and specifications. The brands studied were safe enough and could be used to achieve the desired therapeutic effect.

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Section: Discussionmentioning

confidence: 99%

In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia

Abebe¹,

Beressa²,

Yimer³

2020

DHPS

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“…During irradiation of the polymeric solution, numerous active sites are produced on the polymer chains, which results in extensive cross‐linking. [ 105 ] Irradiation polymerization produces residue‐free, sterile, and highly pure hydrogels. Swelling factors (viz., pore size and cross‐linking) of hydrogels can be readily regulated using this method by changing the radiation exposure.…”

Section: Synthetic Approachesmentioning

confidence: 99%

Hydrogel Nanocomposite Adsorbents and Photocatalysts for Sustainable Water Purification

Kumar

Gusain

Pandey

et al. 2022

Adv Materials Inter

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Anthropogenic actions, environmental catastrophes, urbanization, population growth, and industrialization generate toxic pollutants in water bodies. The most pollutants are heavy metals and metalloids, dyes, volatile organic compounds, pharmaceuticals, pesticides, radionuclides, aromatic hydrocarbons, oils, polycyclic aromatic hydrocarbons, microbes/pathogens, and microplastics that can be in different forms and concentrations. [3][4][5] Globally, approximately 2 million tons of pollutants from agriculture, industrial, and sewage waste are released into water streams, which pose severe health risks and cause the deaths of more than 1400 people every day. [6] Thus, developing efficient, economical, environmentalfriendly, and scalable technologies for the purification of wastewater and seawater is urgently required. To fulfill the shortage of clean water, affordable technologies can be used to transform unconventional water reserves (such as wastewater, rainfall, seawater, and brackish water) into potable water. Recently, numerous water treatment technologies, including coagulation/flocculation, filtration, chemical precipitation, aerobic/anaerobic processing, biological treatment, electrochemically precipitation, advanced oxidation processing, membrane separation, ion-exchange, adsorption, solar/thermal distillation/evaporation, crystallization, and photocatalysis, have emerged to offer practical solutions to water pollution management. [7][8][9][10][11][12][13][14] Among them, adsorption and photocatalysis technologies have garnered significant attention from the research community due to their cost-effectiveness, high performance, Hydrogels have been employed for water purification applications, but their performance and strength are unsatisfactory for widespread adoption. Recently, hydrogel nanocomposites have been proposed to resolve the inherent challenges faced by hydrogels for water treatment. This review comprehensively analyzes hydrogel nanocomposites for water treatment using adsorbent and photocatalysis techniques. The structure, classification, and tunable synthesis methods of hydrogels are explained. Further, how hydrogels can be incorporated with functional nanoparticles (NPs) and can be used as templates/precursors for developing advanced 3D architectures, including the formation of hydrogel nanocomposite beads and 3D printing objects are discussed. Finally, the structure-property relationships of hydrogel nanocomposites are critically reviewed by considering introductory gelation chemistry, such as swelling characteristics, mechanical properties, stimuli-responsiveness, and ionic/electronic conduction. The extensive cross-linking of polymer chains with NPs offers high mass/charge transport, high surface areas, and enhanced polymer-water interactions to achieve high-performing adsorbents and photocatalysts. Several motivating examples of emerging NP-containing hydrogel nanocomposites for use in adsorbents and photocatalysis have been discussed. Such efforts validated the excellent technological pote...

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D-optimal mixture design inspired modified release tablet formulation of lamotrigine for the treatment of seizures: An in-depth characterization

Atneriya,

Sainy,

Chidrawar

et al. 2024

Annales Pharmaceutiques Françaises

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Study of Post Compression Parameters of Various Marketed Paracetamol Tablets in India

Cited by 4 publications

References 0 publications

In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia

In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia

Hydrogel Nanocomposite Adsorbents and Photocatalysts for Sustainable Water Purification

D-optimal mixture design inspired modified release tablet formulation of lamotrigine for the treatment of seizures: An in-depth characterization

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