Study of Potential Mechanisms of Traumatic Rupture of the Aorta Using InSitu Experiments

Hardy, Warren N.; Shah, Chirag; Kopacz, James M.; Yang, King H.; Ee, Chris A. Van; Morgan, Richard M.; Digges, Kennerly H.

doi:10.4271/2006-22-0011

Cited by 15 publications

(23 citation statements)

References 30 publications

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“…Sudden longitudinal stretch of the aorta is a principal factor for traumatic injury in impacts such as are endured in car crashes even though the internal pressure remains low. 17 These impact-induced ruptures are circumferential, but hypertension primarily induces circumferential normal stretch in the artery.…”

Section: Rupture Patterns In Arteriesmentioning

confidence: 99%

The Influence of Medial Substructures on Rupture in Bovine Aortas

Haslach

Riley

Molotsky

2011

Cardiovasc Eng Tech

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The substructures of an aorta wall in hypertension play a critical mechanical role in aorta damage and possible rupture. The goal is to develop a hypothesis for these invisible dynamic mechanisms in a rupturing wall from the rupture surface morphology. Rupture mechanisms suggested by tensile tests, including histological images of the crack, are explored on a novel pneumatic device to expand ring specimens excised from bovine aorta. This technique elucidates the role in rupture of the medial substructures, the wall thickness and the moisture content of the specimen using images of the rupture surface, weight measures, and measurements of the permanent deformation prior to rupture and also at rupture. In both excised aorta tensile strip specimens and ring specimens, collagen fiber pull-out due to shear is a prerequisite for rupture, and is reflected in local permanent deformation that precedes rupture. Some of this permanent deformation is recovered by rehydrating the specimen. In the specimens loaded parallel to the collagen fibers, the change in crack direction shown in histological images of uniaxial specimens is reflected in rings by the acute rupture angle with the load direction. A hypothesis is proposed for the rupture mechanisms in the aorta wall that involves shear of the connections between fascicle substructures in the media. The results suggest requirements for a mathematical model of the aorta wall in hypertension that is more realistic than the usual hyperelastic models.

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Section: Rupture Patterns In Arteriesmentioning

confidence: 99%

The Influence of Medial Substructures on Rupture in Bovine Aortas

Haslach

Riley

Molotsky

2011

Cardiovasc Eng Tech

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“…While Hardy et al (2006) reported intimal and medial aortic injuries, the authors refrained from recording such partial injuries since neither histologic analysis nor pre-test aortic tissue exploration was performed. Test DWN1.…”

Section: Resultsmentioning

confidence: 97%

“…These findings seem to invalidate the potential injury mechanism mentioned by Viano (1983) based on the contribution of the hilar structures as a fulcrum (Zehnder 1956) and downward heart displacement with the neck flexed. In the test ANT3, unlike Hardy et al (2006) who imposed an anterior displacement by distracting the arch or the ascending aorta by means of a strap of nylon webbing, the displacement was imposed on the heart. Although the heart displacement needed experimentally to produce the isthmic rupture seems greater than expected, this test emphasised a potential load of the aorta leading to the classical rupture.…”

Section: Resultsmentioning

confidence: 99%

“…The purpose of the study was to investigate the effect of heart displacements using revascularised human cadaveric specimens. The tests were specifically designed to study the effects of downward and anterior displacements of the heart, which were both assumed to be potential components of TRA mechanisms but without experimental validation (Hardy et al 2006). Hypothesised contribution of the transverse hilar structures as a mechanical 'bar' and fulcrum (Zehnder 1956) was also investigated.…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical study of potential injury mechanisms of thoracic aorta

Bertrand

Potier

Petit

et al. 2009

Computer Methods in Biomechanics and Biomedical Engineering

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“…intraaortic pressure- Bass et al, 2001; distraction of the arch- Hardy et al, 2006;chest compression-Kroell and Schneider, 1974;Nusholtz et al, 1985;Viano et al, 1978;Voigt and Wilfert, 1969). Although none of those studies prove that their respective injury mechanisms are the cause of aortic injury in the field, they do show that those mechanisms can cause aortic injury in the absence of other factors.…”

Section: Article In Pressmentioning

confidence: 92%