The analysis of the existing results of studies on the process of heat and mass transfer, during the evaporation of different model liquids under conditions of ultrasonic exposure and reduced pressure, was carried out. Main results state that the best performances are obtained from kerosene, in terms of evaporation rate, but it is necessary more investigation in order to show a clear dependence on the characteristics of both the ultrasonic waves, namely frequency and amplitude, and the model liquids. The results from the mathematical modeling of the process of evaporation of a model liquid were obtained in the form of temperature variation of the liquid, at different frequencies of the acoustic waves (22 kHz, 30 kHz, 37 kHz) and at an amplitude of the oscillations of the bottom of the bath of 2 µm. Both program and methodology for conducting experiments on the evaporation of a liquid, under reduced pressure and at different frequencies of acoustic waves, have been developed. The initial data, variable parameters, assumptions and limitations for conducting experiments were determined. Piezoceramic emitters were used as emitters of ultrasonic waves, with the same frequencies of the acoustic wave and amplitude of the oscillations of the bottom of the bath used in the mathematical model.