In this study, we introduce a recent approach to implement the wavelet analysis of ionospheric parameters and anomaly detection during ionospheric irregularities over Pakistan. The most important aspect of the wavelet analysis is the timefrequency distribution representation of the signal. This study investigates the variability of ionospheric F2 layer and utilizes critical frequency (foF2) of F2 layer during the year 2008-2017 in Pakistan region. The results of this study identify the most important bands of low frequency variations, which are very relevant for study of periodicities measurements of F2 layer. Moreover, Morlet wavelet has revealed that generally the global wavelet power spectrum (GWPS) is the most prominent in the annual cycles. The multifaceted interactions of ionospheric fluctuations with different time scales, e.g. annual, biannual, become significant due to higher peaks appear during the periods 128-256, 256-512 and 512-1024 days in daily data sets. The wavelet trend revales a noticeablel power range between the 2–16 day bands, representing an annual fluctuation for daily observations of F2 layer. The low deviation in a frequency range highlights the existence of seasonality in the F2 layer during the study period. These results emphasize that foF2 observations exhibit irregular distrabances with non-stationary power at different frequencies.The study will be helpful for stakeholders and government authorities because high frequency sky-waves users schedule their programs one month in advance, but they also need day by day information about the ionospheric conditions in order to revise programs.