Study of Red Cell Fragility in Different Stages of Chronic Kidney Disease in Relation to Parathyroid Hormone

Panda, Suchismita; Mishra, Anuva; Jena, Manoranjan; Rout, Sashi Bhusan; Mohapatra, Srikrushna

doi:10.7860/jcdr/2017/27344.10514

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…There was a significant reduction in hemoglobin levels with decreasing eGFR values as previously reported [ 46 ]. The primary cause of anemia is a reduction in EPO synthesis due to loss of renal functional mass [ 47 ].…”

Section: Discussionsupporting

confidence: 84%

Association between Serum Magnesium and Hemoglobin in Patients with Primary Hyperparathyroidism

Ding

Guo

Liu

et al. 2021

International Journal of Endocrinology

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Background. There is a positive association between serum magnesium and hemoglobin levels in the general population. However, no studies have evaluated the association between serum magnesium and hemoglobin levels in patients with primary hyperparathyroidism (PHPT). We aimed to investigate whether there is a relationship between serum magnesium and hemoglobin levels in the patient population with PHPT. Methods. This retrospective study included 307 hospitalized PHPT patients who were continuously admitted to the Second Xiangya Hospital of Central South University, from January 2010 to August 2020. Laboratory and demographic data of patients were collected. Hypomagnesemia was defined as serum magnesium <0.75 mmol/L. Patients with a hemoglobin level below 130 g/L in males and below 120 g/L in females were accepted as the anemic group. Results. Among the 307 patients with PHPT included in our study, 77 (25.1%) patients (33 (32.4%) males and 44 (21.5%) females) had hypomagnesemia. A total of 138 (45.0%) patients (49 males (48.0%) and 89 females (43.4%)) had anemia. Compared with the nonanemic group, the anemic group had lower average albumin, eGFR, and serum magnesium levels in both males and females. In contrast, average creatinine, PTH, and corrected calcium were significantly higher in the anemic group than in the nonanemic group in both males and females. Lower serum magnesium levels were associated with lower hemoglobin levels independent of serum calcium, albumin, eGFR, and PTH in PHPT patients. Conclusions. Hypomagnesemia is a common electrolyte disorder in PHPT patients. Hypomagnesemia is independently associated with lower hemoglobin levels in patients with PHPT.

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Section: Discussionsupporting

confidence: 84%

Association between Serum Magnesium and Hemoglobin in Patients with Primary Hyperparathyroidism

Ding

Guo

Liu

et al. 2021

International Journal of Endocrinology

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“…This confirms the shortened survival of RBC with the progression of renal dysfunction. This came in agrement with Panda et al who reported a statistically significant increase in the MOF with increasing the stage of CKD (0.35% ± 0.12%, 0.48% ± 0.11%, 0.62% ± 0.07% and 0.65% ± 0.66% in stage II, III A, III B and IV CKD respectively) [14]. In this study, there was a statistically significant string positive correlation between MOF and PTH levels (r = 0.836, P < 0.001*) (Table 4).…”

Section: Discussionsupporting

confidence: 54%

“…In the study conducted by Panda and his colleagues, ROC analysis revealed an area under the curve of 0.980 with a sensitivity of 100% and specificity of 87% in detecting osmotic fragility at a cut-off value of PTH ≥ 100 pg/ml [14]. There is also a statistically significant positive correlation between MOF with Creatinine, Urea, Phosphorous, Ca*phosphorous product, K, KTV and PTH (Table 5).…”

Section: Discussionmentioning

confidence: 92%

“…Several studies have revealed the association of hyperparathyroidism with CKD. Parathyroid hormone (PTH) is a major uremic toxin which may be responsible for long term consequences in CKD such as renal osteodystrophy, vascular calcification, altered cardiovascular function, immune dysfunction and anaemia [1]. One of the lesser known functions of the kidneys is the production of erythropoietin, a signaling molecule that stimulates red blood cell production, in response to decreased oxygen levels in the blood.…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid Hormone as a Marker for the Red Cell Fragility in Different Stages of Chronic Kidney Disease

Khamis¹,

Mohamed²,

Kasem³

et al. 2021

OJNeph

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Objective: The aim of the work is to study the relationship between Red blood cell osmotic fragility and level of parathyroid hormone in patients with different stages of Chronic Kidney Disease including End Stage Renal Disease. Background: Anaemia is one of the common complications associated with Chronic Kidney Disease (CKD) responsible for the increase in the morbidity and mortality in such patients. Several factors have been attributed to causing renal anaemia, amongst which hyperparathyroidism is one of the less recognised reasons. The level of PTH in early stages of chronic kidney disease has not been much studied. The excess amount of Parathyroid Hormone (PTH) secondary to CKD has been suggested to be a causative factor for anaemia. Method: A number of chronic kidney disease patients were studied for the relationship between Red cell osmotic fragility and level of parathyroid hormone. Results: This study was conducted on a number of 111 patients with chronic kidney disease classified into three groups. The study revealed a significant fall in Hb%, along with a rise in Median Osmotic Fragility (MOF) and PTH in the CKD patients. iPTH and MOF were significantly lower in group 3 as compared with cases in group 1. Also, iPTH and MOF were significantly lower in cases in group 2 as compared with cases in group 1. Conclusions: Based on our findings, secondary hyperparathyroidism has considerable effects on erythrocyte survival, contributing to increased fragility and anemia.

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“…In all the groups the fall of urea corresponds to the excess discharge of nitrogen, indicating the overwork of kidneys or load on kidneys plus disturbance in metabolism of nitrogen. This may relate to alteration in parathyroid hormone [33] by influence by atorvastatin. The fall may be due to nephrotoxic effect in this dose where inhibition of p38mitogen-activated protein kinase (MAPK), as well as nuclear factor kappa-β (NF-κβ) signaling pathways, and inducible nitric oxide synthase (NOS) expression is altered [34].…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Toxicological Evaluation of Atorvastatin and Riboflavin in Diethylnitrosamine Induced Hepatocellular Carcinoma

Mohammed¹,

Sadath²,

Jamal³

et al. 2018

JPRI

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Background: Atorvastatin, a commonly prescribed drug for the management of hyperlipidemia, acts as competitive inhibitors of HMG-CoA reductase-a rate-limiting enzyme in cholesterol synthesis. On the other hand, riboflavin is also a well-studied micronutrient known for its anti-proliferative, antimetastatic and antioxidant properties. However, the synergistic or antagonistic effect of both drugs when administered together is not studied yet. Method: This study was an attempt to evaluate the toxicity/efficacy of atorvastatin (30 mg/kg) in combination with riboflavin in hepatocarcinogenic rats when challenged by a single diethylnitrosamine DENA (160 mg/kg; I.

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Study of Red Cell Fragility in Different Stages of Chronic Kidney Disease in Relation to Parathyroid Hormone

Abstract: The underlying cause of anaemia should be identified early in the CKD patients before haemodialysis. Secondary hyperparathyroidism should be ruled out as a causative factor of anaemia to slow down the progression of the disease process.

Cited by 7 publications

References 21 publications

Association between Serum Magnesium and Hemoglobin in Patients with Primary Hyperparathyroidism

Association between Serum Magnesium and Hemoglobin in Patients with Primary Hyperparathyroidism

Parathyroid Hormone as a Marker for the Red Cell Fragility in Different Stages of Chronic Kidney Disease

Biochemical and Toxicological Evaluation of Atorvastatin and Riboflavin in Diethylnitrosamine Induced Hepatocellular Carcinoma

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