Study of Relation between Serum Magnesium Levels and Vascular Complications in Patients of Type 2 Diabetes Mellitus

Dineshbabu, S; Tonk, Rajinder Singh

doi:10.18535/ijmsci/v6i9.03

Cited by 1 publication

(1 citation statement)

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“…34 Dineshbabu and Tonk in their recent study concluded hypomagnesemia in T2DM was correlated with various complications and stated magnesium can be considered as a nutritional supplement in patients with diabetes to reduce the incidence of vascular complications. 35 Subjects with type 2 diabetes showed a strong relationship with foot ulcers with depleted serum magnesium. 36 Duration of diabetic foot ulcers (grade I and II) increased with duration of diabetes increase and serum magnesium decrease.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Variations of Serum Magnesium with Lipid Analytes in Different Clinical Groups of Type 1 and Type 2 Diabetes Mellitus: A Hospital-based Cross-sectional Study

Kumar¹,

Kant²,

Naithani³

et al. 2020

Indian Journal of Medical Biochemistry

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Objective: Hypomagnesemia associated with dyslipidemia in type 2 diabetes mellitus (T2DM) has been well documented globally by various researchers, as there found a paucity in related data for type 1 diabetes mellitus (T1DM), present observational hospital-based cross-sectional study was planned to estimate, correlate serum magnesium with lipid analytes in different clinical groups of both T1DM and T2DM, and validate its diagnostic significance. Materials and methods:The study comprised 250 subjects with random inclusion of 200 of both T1DM, T2DM, and 50 normoglycemic healthy controls. Based on medical history and clinical records of 52 T1DM and 148 T2DM clinical cases, they were subgrouped into group I-newly diagnosed, group II-stabilized controlled, and group III-with long course, uncontrolled with associated complications. Biochemical analyses of plasma glucose, serum total magnesium, total cholesterol, and triacylglycerol were analyzed, compared, and correlated statistically with each group and healthy controls. Results: Comparison and correlations of studied analytes in T1DM and T2DM groups of subgroups with healthy controls, clearly depicted biochemical variations of hypomagnesemia in overt hyperglycemic-hyperlipidemic clinical cases. Hypomagnesemia was inversely correlated with hypertriacylglycerolemia and hypercholesterolemia in hyperglycemic of both T1DM and T2DM with varied statistical significances in different clinical groups with (p < 0.001) in group III, (p < 0.01) in group I, and (p > 0.05) non-significant in group II. However, no statistical significance (p > 0.05) for analytes was noted between type 1 and type 2 of all subgroups. Conclusion: As biochemical variations of hypomagnesemia in overt hyperglycemic-hyperlipidemic type 1 and type 2 clinical cases of diabetes mellitus was depicted and correlated, it is recommended for clinicians to prescribe serum magnesium as a routine investigation of diabetes diagnostic profile for early screening, periodic monitoring, and better management with its supplementation to prevent long-standing critical diabetes complications.

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Section: Discussionmentioning

confidence: 99%