Study of Relatives of Persons With Fibrillopathia Epitheliocapsularis (Pseudoexfoliation of the Lens Capsule)

Aasved, Henry

doi:10.1111/j.1755-3768.1975.tb00406.x

Cited by 47 publications

(31 citation statements)

References 9 publications

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“…The prevalence appears rather similar in those countries where mass screening or population based surveys have been conducted (Aasved 1969(Aasved , 1971Hiller et al 1982); however, racial differences (Forsius & Luukka 1973), and occurrence in cer-tain families (Forsius & Eriksson 1961;Tarkkanen 1962;Aasved 1969Aasved , 1975 have been recorded. The prevalence appears rather similar in those countries where mass screening or population based surveys have been conducted (Aasved 1969(Aasved , 1971Hiller et al 1982); however, racial differences (Forsius & Luukka 1973), and occurrence in cer-tain families (Forsius & Eriksson 1961;Tarkkanen 1962;Aasved 1969Aasved , 1975 have been recorded.…”

Section: Introductionmentioning

confidence: 88%

Exfoliation Syndrome Among Saudis

Summanen

Tønjum

1988

Acta Ophthalmologica

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The prevalence of exfoliation syndrome among Saudis was determined during the National Survey of Blindness and Eye Disease in 1984 in Kingdom of Saudi Arabia. The subsample of this study consists of 376 persons aged 40 years or more from 50 different locations examined under mydriasis by the authors using Kowa hand-held microscope. There were 192 men and 184 women with the mean age of 56.0 f 1.2 years (median 53.5 years, range 40-95 years).The overall prevalence of exfoliation syndrome was 9.3 Yo: in the age group 40 to 49 years 1.6 Yo, 50 to 59 years 7.8 Yo, 60 to 69 years 8.9 Yo, and 26.5 Yo in persons 70 years of age and over. No significant association was found between exfoliation syndrome and sex or parental kinship.In 16 persons the exfoliation syndrome was unilateral, and in 19 persons bilateral. In 24 eyes the phenomenon could not be evaluated due to the anterior segment pathology.Exfoliation syndrome was associated with higher intraocular pressure (20 f 3 mmHg (n = 49) vs. 17 f 0.4 mmHg (n = 601), P < 0.05), and more cataract changes (P < 0.001) than eyes without. These eyes were also associated with poorer visual acuity than the eyes without exfoliation syndrome: in 26 of 35 persons with exfoliation syndrome, the affected eye was the better eye but in 35 Yo the vision was < 0.05 (< 3/60) i.e. the person was blind, compared to 6 Yo of persons whose better eye did not have exfoliation syndrome (P < 0.001).

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Section: Introductionmentioning

confidence: 88%

Exfoliation Syndrome Among Saudis

Summanen

Tønjum

1988

Acta Ophthalmologica

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“…In Iceland the prevalence is 17.7% in patients aged 70 to 79 years and reached up to 40.6% in patients aged above 80 [20] years. PXS was also found to be generally more prevalent in men than in women [21]; this gender association though is not always reproducible [20]. The incidence of PXS roughly doubles each decade of life after the age of 50 [22] years.…”

Section: Pxs Demographicsmentioning

confidence: 99%

Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations

et al. 2012

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Pseudoexfoliation syndrome (PXS) is a systemic condition with eye manifestations. In the eye, pseudoexfoliation material deposits on various structures of the anterior segment. The nature of this material is mostly fibrillar with fibers made up of microfibrils and coated with amorphous material. The composition of these fibrils is diverse and includes basement membrane components as well as enzymes involved in extracellular matrix maintenance. Pseudoexfoliation is the most common cause of secondary open-angle glaucoma (pseudoexfoliation glaucoma, PXG) worldwide. The goal of this review is to summarize our knowledge on the genetics of this systemic disorder and its resultant ocular manifestations. PXS familial aggregation suggests genetic inheritance. PXS has been strongly associated with single nucleotide polymorphisms (SNPs) of the lysyl oxidase-like 1 (LOXL1) gene on chromosome 15q24.1. Two of these SNPs confer a higher than 99% population attributable risk for PXS and PXG in the Nordic population; however, they carry different risks in different populations. The high risk haplotypes also vary among different populations. LOXL1 is one of group of the enzymes involved in the cross-linking of collagen and elastin in the extracellular matrix. Its function in connective tissue maintenance has been confirmed in mice; however, its actual role in PXS remains unclear. Contactin-associated protein-like 2 also has a strong genetic association with PXS in a German cohort and is an attractive candidate molecule. It encodes for a protein involved in potassium channel trafficking. Other candidate genes linked to PXS include lysosomal trafficking regulator, clusterin, adenosine receptors, matrix metalloproteinase-1 (MMP1), and glutathione transferase. These genes may be modifying genes for development of PXS and PXG.

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“…A few studies (Tarkkanen 1962;Pohjanpelto & Hurskainen 1972;Aasved 1975;Damji et al 1999;Allingham et al 2001;Orr et al 2001) in families consisting of between two and four generations have been described. Depending upon the study material, different modes of inheritance have been suggested: autosomal dominant (Tarkkanen 1962;Aasved 1975;Orr et al 2001), autosomal recessive (Andersen et al 1997) and maternal transmissions such as X-linked, mitochondrial and autosomal inheritance with genomic imprinting (Damji et al 1999). The main problem for investigations of the genetic background of ES has been the late onset of ES, where previous generations are often deceased at the time when the current generation is manifesting exfoliative changes.…”

Section: Introductionmentioning

confidence: 99%